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MT001428

UniProt Annotations

Entry Information

Gene Name	carbonyl reductase 4
Protein Entry	CBR4_HUMAN
UniProt ID	Q8N4T8
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N4T8-1; Sequence=Displayed; Name=2; IsoId=Q8N4T8-2; Sequence=VSP_031527; Note=No experimental confirmation available.;
Biophysicochemical Properties	Kinetic parameters: KM=11 uM for NADPH; KM=1.6 uM for 9,10-phenanthrenequinone; KM=1.9 uM for 1,4-benzoquinone; pH dependence: Optimum pH is 6-8.;
Function	The heteroteramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). {ECO:0000269\|PubMed:19000905, ECO:0000269\|PubMed:19571038}.
Pathway	Lipid metabolism; fatty acid biosynthesis.
Similarity	Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location	Mitochondrion matrix {ECO:0000269\|PubMed:19000905, ECO:0000269\|PubMed:19571038}.
Subunit	Homotetramer. Heterotetramer with HSD17B8; contains two molecules of HSD17B8 and CBR4. {ECO:0000269\|PubMed:19000905}.
Tissue Specificity	Detected in liver and kidney (at protein level). {ECO:0000269\|PubMed:19000905}.