MitoProteome Database

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MT001432

UniProt Annotations

Entry Information

Gene Name	ATPase family, AAA domain containing 1
Protein Entry	ATAD1_HUMAN
UniProt ID	Q8NBU5
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NBU5-1; Sequence=Displayed; Name=2; IsoId=Q8NBU5-2; Sequence=VSP_037304;
Catalytic Activity	ATP + H(2)O = ADP + phosphate.
Function	ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA- stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity). {ECO:0000250}.
Similarity	Belongs to the AAA ATPase family. {ECO:0000305}.
Subcellular Location	Peroxisome {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.
Subunit	Interacts with GRIA2 and GRIP1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts not only its binding to GRIA2 and GRIP1, but also interaction between GRIP1 and GRIA2, leading to AMPAR complex disassembly (By similarity). {ECO:0000250}.