MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MT001449

UniProt Annotations

Entry Information

Gene Name	cytosolic thiouridylase subunit 1
Protein Entry	CTU1_HUMAN
UniProt ID	Q7Z7A3
Species	Human

Comments

Comment type	Description
Function	Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255\|HAMAP-Rule:MF_03053, ECO:0000269\|PubMed:19017811}.
Pathway	tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine- tRNA biosynthesis. {ECO:0000255\|HAMAP-Rule:MF_03053}.
Similarity	Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily. {ECO:0000255\|HAMAP-Rule:MF_03053}.
Subcellular Location	Cytoplasm.
Subunit	Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2. {ECO:0000255\|HAMAP-Rule:MF_03053, ECO:0000269\|PubMed:19017811}.