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MT001513

UniProt Annotations

Entry Information

Gene Name	acyl-CoA synthetase medium-chain family member 2A
Protein Entry	ACS2A_HUMAN
UniProt ID	Q08AH3
Species	Human

Comments

Comment type	Description
Catalytic Activity	ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269\|PubMed:19345228, ECO:0000269\|Ref.5}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269\|PubMed:19345228, ECO:0000269\|Ref.5};
Function	Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). {ECO:0000250}.
Sequence Caution	Sequence=AAC23497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location	Mitochondrion matrix {ECO:0000250}.
Subunit	Monomer. {ECO:0000250}.