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MT001521

UniProt Annotations

Entry Information

Gene Name	carnitine palmitoyltransferase 1C
Protein Entry	CPT1C_HUMAN
UniProt ID	Q8TCG5
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TCG5-1; Sequence=Displayed; Name=2; IsoId=Q8TCG5-2; Sequence=VSP_010677; Note=No experimental confirmation available.; Name=3; IsoId=Q8TCG5-3; Sequence=VSP_012457; Note=No experimental confirmation available.;
Catalytic Activity	Palmitoyl-CoA + L-carnitine = CoA + L- palmitoylcarnitine.
Pathway	Lipid metabolism; fatty acid beta-oxidation.
Sequence Caution	Sequence=BAB85068.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD38561.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity	Belongs to the carnitine/choline acetyltransferase family. {ECO:0000305}.
Subcellular Location	Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}.
Subunit	Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including CPT1C. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed predominantly in brain and testis. {ECO:0000269\|PubMed:12376098}.