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MT001524

UniProt Annotations

Entry Information

Gene Name	apolipoprotein A-I binding protein
Protein Entry	NNRE_HUMAN
UniProt ID	Q8NCW5
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8NCW5-1; Sequence=Displayed; Name=2; IsoId=Q8NCW5-2; Sequence=VSP_026417;
Catalytic Activity	(6R)-6-beta-hydroxy-1,4,5,6- tetrahydronicotinamide-adenine dinucleotide = (6S)-6-beta-hydroxy- 1,4,5,6-tetrahydronicotinamide-adenine dinucleotide.
Catalytic Activity	(6R)-6-beta-hydroxy-1,4,5,6- tetrahydronicotinamide-adenine dinucleotide phosphate = (6S)-6- beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate.
Cofactor	Name=K(+); Xref=ChEBI:CHEBI:29103; Evidence={ECO:0000255\|HAMAP-Rule:MF_03159}; Note=Binds 1 potassium ion per subunit. {ECO:0000255\|HAMAP- Rule:MF_03159};
Function	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. {ECO:0000255\|HAMAP-Rule:MF_03159}.
Ptm	Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation. {ECO:0000255\|HAMAP- Rule:MF_03159}.
Similarity	Belongs to the NnrE/AIBP family. {ECO:0000255\|HAMAP- Rule:MF_03159}.
Similarity	Contains 1 YjeF N-terminal domain. {ECO:0000255\|HAMAP- Rule:MF_03159}.
Subcellular Location	Mitochondrion {ECO:0000255\|HAMAP- Rule:MF_03159}. Secreted {ECO:0000255\|HAMAP-Rule:MF_03159, ECO:0000269\|PubMed:11991719}. Note=In sperm, secretion gradually increases during capacitation. {ECO:0000255\|HAMAP-Rule:MF_03159}.
Subunit	Homodimer (By similarity). Interacts with APOA1 and APOA2. {ECO:0000255\|HAMAP-Rule:MF_03159, ECO:0000269\|PubMed:11991719}.
Tissue Specificity	Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level). {ECO:0000269\|PubMed:11991719}.