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MT001545

Record overview

MITO IDMT001545
Gene ID137872
SpeciesHomo sapiens (Human)
Gene Namealcohol dehydrogenase, iron containing, 1
Gene SymbolADHFE1
SynonymsHOT; ADH8; HMFT2263;
Alternate nameshydroxyacid-oxoacid transhydrogenase, mitochondrial; alcohol dehydrogenase 8; Fe-containing alcohol dehydrogenase 1; alcohol dehydrogenase iron-containing protein 1;
Chromosome8
Map Location8q13.1
EC Number1.1.99.24
SummaryThe ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for ADHFE1

Proteins

hydroxyacid-oxoacid transhydrogenase, mitochondrial
Refseq ID:NP_653251
Protein GI:133922590
UniProt ID:Q8IWW8
mRNA ID:NM_144650
Length:467
RefSeq Status:
MAAAARARVAYLLRQLQRAACQCPTHSHTYSQAPGLSPSGKTTDYAFEMAVSNIRYGAAVTKEVGMDLKNMGAKNVCLMTDKNLSKLPPVQVAMDSLVKN
GIPFTVYDNVRVEPTDSSFMEAIEFAQKGAFDAYVAVGGGSTMDTCKAANLYASSPHSDFLDYVSAPIGKGKPVSVPLKPLIAVPTTSGTGSETTGVAIF
DYEHLKVKIGITSRAIKPTLGLIDPLHTLHMPARVVANSGFDVLCHALESYTTLPYHLRSPCPSNPITRPAYQGSNPISDIWAIHALRIVAKYLKRAVRN
PDDLEARSHMHLASAFAGIGFGNAGVHLCHGMSYPISGLVKMYKAKDYNVDHPLVPHGLSVVLTSPAVFTFTAQMFPERHLEMAEILGADTRTARIQDAG
LVLADTLRKFLFDLDVDDGLAAVGYSKADIPALVKGTLPQERVTKLAPCPQSEEDLAALFEASMKLY