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MT001548

UniProt Annotations

Entry Information

Gene Name	apolipoprotein O-like
Protein Entry	MIC27_HUMAN
UniProt ID	Q6UXV4
Species	Human

Comments

Comment type	Description
Function	Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. {ECO:0000269\|PubMed:23704930}.
Miscellaneous	Overexpression of APOOL results in mitochondrial fragmentation, reduced oxygen consumption, and altered cristae morphology. Down-regulation impairs mitochondrial function and also alters cristae morphology (PubMed:23704930). {ECO:0000305\|PubMed:23704930}.
Sequence Caution	Sequence=CAI42458.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane {ECO:0000269\|PubMed:23704930}; Multi-pass membrane protein {ECO:0000269\|PubMed:23704930}.
Subunit	Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27 and IMMT/MIC60. The complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2, and with HSPA9. {ECO:0000269\|PubMed:23704930}.