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MT001550

UniProt Annotations

Entry Information

Gene Name	ankyrin repeat and SOCS box containing 9
Protein Entry	ASB9_HUMAN
UniProt ID	Q96DX5
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96DX5-1; Sequence=Displayed; Name=2; Synonyms=ASB9deltaSOCS; IsoId=Q96DX5-2; Sequence=VSP_000271; Note=Does not interact with the Elongin BC complex, likely to be a negative regulator of isoform 1.; Name=3; IsoId=Q96DX5-3; Sequence=VSP_043158, VSP_000271; Note=No experimental confirmation available.;
Domain	The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin- protein ligase complexes. {ECO:0000250}.
Function	Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A. {ECO:0000269\|PubMed:22418839}.
Interaction	P12277:CKB; NbExp=3; IntAct=EBI-745641, EBI-357706; Q9NWT6:HIF1AN; NbExp=3; IntAct=EBI-745641, EBI-745632;
Pathway	Protein modification; protein ubiquitination.
Sequence Caution	Sequence=CAB45706.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Contains 1 SOCS box domain. {ECO:0000255\|PROSITE- ProRule:PRU00194}.
Similarity	Contains 6 ANK repeats. {ECO:0000255\|PROSITE- ProRule:PRU00023}.
Subcellular Location	Mitochondrion {ECO:0000269\|PubMed:20302626}.
Tissue Specificity	Predominantly expressed in testis, kidney, and liver. {ECO:0000269\|PubMed:20302626}.