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MT001552

UniProt Annotations

Entry Information

Gene Name	dynein, light chain, LC8-type 2
Protein Entry	DYL2_HUMAN
UniProt ID	Q96FJ2
Species	Human

Comments

Comment type	Description
Function	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). {ECO:0000250}.
Interaction	P0C206:- (xeno); NbExp=4; IntAct=EBI-742371, EBI-9675596; Q85601:- (xeno); NbExp=3; IntAct=EBI-742371, EBI-9676175;
Similarity	Belongs to the dynein light chain family. {ECO:0000305}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000250}.
Subunit	Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. Dynein ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNC1I1. Interacts with BMF. Component of the myosin V motor complex. Interacts with rabies virus phosphoprotein (By similarity). {ECO:0000250}.