MitoProteome Database

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MT001559

UniProt Annotations

Entry Information

Gene Name	apoptosis-inducing factor, mitochondrion-associated, 3
Protein Entry	AIFM3_HUMAN
UniProt ID	Q96NN9
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96NN9-1; Sequence=Displayed; Name=2; IsoId=Q96NN9-2; Sequence=VSP_021300, VSP_021303; Name=3; IsoId=Q96NN9-3; Sequence=VSP_021303; Note=No experimental confirmation available.;
Domain	The Rieske domain induces apoptosis.
Function	Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. {ECO:0000269\|PubMed:15764604}.
Similarity	Belongs to the FAD-dependent oxidoreductase family. {ECO:0000305}.
Similarity	Contains 1 Rieske domain. {ECO:0000255\|PROSITE- ProRule:PRU00628}.
Subcellular Location	Mitochondrion {ECO:0000269\|PubMed:15764604}. Note=Does not translocate to the nucleus upon induction of apoptosis.
Tissue Specificity	Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and tongue (at protein level). {ECO:0000269\|PubMed:15764604}.