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MT001577

UniProt Annotations

Entry Information

Gene Name	dishevelled-binding antagonist of beta-catenin 2
Protein Entry	DACT2_HUMAN
UniProt ID	Q5SW24
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5SW24-1; Sequence=Displayed; Name=2; IsoId=Q5SW24-2; Sequence=VSP_032596; Note=No experimental confirmation available.; Name=3; IsoId=Q5SW24-3; Sequence=VSP_032595; Note=No experimental confirmation available.; Name=4; IsoId=Q5SW24-4; Sequence=VSP_032597, VSP_032598; Note=No experimental confirmation available.;
Domain	The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins. {ECO:0000250}.
Function	Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity). {ECO:0000250}.
Sequence Caution	Sequence=AAI11791.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL55843.1; Type=Frameshift; Positions=247; Evidence={ECO:0000305};
Similarity	Belongs to the dapper family. {ECO:0000305}.
Subunit	Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, CSNK2B, DVL1, DVL2, DVL3, VANGL1, VANGL2, TGFBR1, CTNNB1, CTNND2, CTNND1, LEF1, TCF7, TCF7L1 and HDAC1 (By similarity). {ECO:0000250}.