MitoProteome Database

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MT001578

UniProt Annotations

Entry Information

Gene Name	basic helix-loop-helix family, member a15
Protein Entry	BHA15_HUMAN
UniProt ID	Q7RTS1
Species	Human

Comments

Comment type	Description
Domain	Lacks a classic transcription activation domain and instead possesses an N-terminal region capable of inhibiting heterologous activators. {ECO:0000250}.
Function	Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E- box occupancy by homodimers. May also negatively regulate bHLH- mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E- box consensus sequence 5'-CANNTG-3' (By similarity). {ECO:0000250}.
Similarity	Contains 1 bHLH (basic helix-loop-helix) domain. {ECO:0000255\|PROSITE-ProRule:PRU00981}.
Subcellular Location	Nucleus {ECO:0000305}.
Subunit	Forms homodimers or heterodimers with TCF3 gene products E12 and E47. These dimers bind to the E-box site, however, heterodimer with MYOD1 does not bind target DNA (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in brain, liver, spleen and skeletal muscle. {ECO:0000269\|PubMed:14516699}.