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MT001632

UniProt Annotations

Entry Information

Gene Name	COX18 cytochrome c oxidase assembly factor
Protein Entry	COX18_HUMAN
UniProt ID	Q8N8Q8
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=Hs1; IsoId=Q8N8Q8-1; Sequence=Displayed; Name=2; Synonyms=Hs2; IsoId=Q8N8Q8-2; Sequence=VSP_022312, VSP_022314; Name=3; Synonyms=Hs3; IsoId=Q8N8Q8-3; Sequence=VSP_022311, VSP_022315; Name=4; IsoId=Q8N8Q8-4; Sequence=VSP_022313, VSP_022316; Note=No experimental confirmation available.;
Function	Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the COX2 protein into the mitochondrial intermembrane space. {ECO:0000269\|PubMed:16911509}.
Sequence Caution	Sequence=AAH71812.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Similarity	Belongs to the OXA1/ALB3/YidC family. {ECO:0000305}.
Subcellular Location	Mitochondrion inner membrane {ECO:0000269\|PubMed:16212937}; Multi-pass membrane protein {ECO:0000269\|PubMed:16212937}.