MitoProteome Database

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MT001636

UniProt Annotations

Entry Information

Gene Name	bone morphogenetic protein/retinoic acid inducible neural-specific 3
Protein Entry	BRNP3_HUMAN
UniProt ID	Q76B58
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q76B58-1; Sequence=Displayed; Name=2; IsoId=Q76B58-2; Sequence=VSP_055545, VSP_055546; Note=No experimental confirmation available.;
Function	Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development. {ECO:0000269\|PubMed:17138656}.
Similarity	Belongs to the BRINP family. {ECO:0000305}.
Similarity	Contains 1 MACPF domain. {ECO:0000305}.
Subcellular Location	Secreted {ECO:0000305}. Mitochondrion {ECO:0000250}.
Tissue Specificity	Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues. {ECO:0000269\|PubMed:17138656, ECO:0000269\|PubMed:18430236, ECO:0000269\|PubMed:19787213}.