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MT001644

UniProt Annotations

Entry Information

Gene Name	acyl-CoA synthetase medium-chain family member 2B
Protein Entry	ACS2B_HUMAN
UniProt ID	Q68CK6
Species	Human

Comments

Comment type	Description
Catalytic Activity	ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269\|PubMed:10434065}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269\|PubMed:10434065};
Enzyme Regulation	Activated by monovalent cations, such as potassium, rubidium or ammonium. {ECO:0000269\|PubMed:10434065}.
Function	Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). {ECO:0000269\|PubMed:12616642}.
Similarity	Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location	Mitochondrion matrix {ECO:0000269\|PubMed:10434065, ECO:0000269\|PubMed:12616642, ECO:0000269\|PubMed:19634011}.
Subunit	Monomer. {ECO:0000269\|PubMed:12616642}.
Tissue Specificity	Detected in liver. {ECO:0000269\|PubMed:10434065, ECO:0000269\|PubMed:19634011}.