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MT001645

UniProt Annotations

Entry Information

Gene Name	cytosolic thiouridylase subunit 2 homolog (S. pombe)
Protein Entry	CTU2_HUMAN
UniProt ID	Q2VPK5
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q2VPK5-1; Sequence=Displayed; Name=2; IsoId=Q2VPK5-3; Sequence=VSP_025950; Note=No experimental confirmation available.; Name=3; IsoId=Q2VPK5-5; Sequence=VSP_039378; Note=Incomplete sequence.;
Function	Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255\|HAMAP-Rule:MF_03054, ECO:0000269\|PubMed:19017811}.
Pathway	tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine- tRNA biosynthesis. {ECO:0000255\|HAMAP-Rule:MF_03054}.
Similarity	Belongs to the CTU2/NCS2 family. {ECO:0000255\|HAMAP- Rule:MF_03054}.
Subcellular Location	Cytoplasm.
Subunit	Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. {ECO:0000255\|HAMAP-Rule:MF_03054, ECO:0000269\|PubMed:19017811}.