MitoProteome Database

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MT001679

UniProt Annotations

Entry Information

Gene Name	creatine kinase, mitochondrial 1A
Protein Entry	KCRU_HUMAN
UniProt ID	P12532
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P12532-1; Sequence=Displayed; Name=2; IsoId=P12532-2; Sequence=VSP_038045;
Catalytic Activity	ATP + creatine = ADP + phosphocreatine. {ECO:0000255\|PROSITE-ProRule:PRU10029}.
Function	Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Miscellaneous	Mitochondrial creatine kinase binds cardiolipin.
Similarity	Belongs to the ATP:guanido phosphotransferase family. {ECO:0000255\|PROSITE-ProRule:PRU00842, ECO:0000255\|PROSITE- ProRule:PRU00843}.
Similarity	Contains 1 phosphagen kinase C-terminal domain. {ECO:0000255\|PROSITE-ProRule:PRU00843}.
Similarity	Contains 1 phosphagen kinase N-terminal domain. {ECO:0000255\|PROSITE-ProRule:PRU00842}.
Subcellular Location	Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.
Subunit	Exists as an octamer composed of four MTCK homodimers. {ECO:0000269\|PubMed:10737943}.