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MT000018

Record overview

MITO IDMT000018
Gene ID189
SpeciesHomo sapiens (Human)
Gene Namealanine-glyoxylate aminotransferase
Gene SymbolAGXT
SynonymsAGT; PH1; SPT; AGT1; SPAT; TLH6; AGXT1;
Alternate namesserine--pyruvate aminotransferase; serine-pyruvate aminotransferase; serine:pyruvate aminotransferase; alanine--glyoxylate aminotransferase; L-alanine: glyoxylate aminotransferase 1; hepatic peroxisomal alanine:glyoxylate aminotransferase;
Chromosome2
Map Location2q37.3
EC Number2.6.1.51
SummaryThis gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for AGXT

Proteins

serine--pyruvate aminotransferase
Refseq ID:NP_000021
Protein GI:4557289
UniProt ID:P21549
mRNA ID:NM_000030
Length:392
RefSeq Status:
MASHKLLVTPPKALLKPLSIPNQLLLGPGPSNLPPRIMAAGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDSF
LVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGESSTGVLQPLDGFGELCHRYKCLLLVDSVASLGGTPLYMDRQGI
DILYSGSQKALNAPPGTSLISFSDKAKKKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIPVISLYSLRESLALIAEQGLENSWRQHREAAAYLHG
RLQALGLQLFVKDPALRLPTVTTVAVPAGYDWRDIVSYVIDHFDIEIMGGLGPSTGKVLRIGLLGCNATRENVDRVTEALRAALQHCPKKKL