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MT000021

Record overview

MITO IDMT000021
Gene ID207
SpeciesHomo sapiens (Human)
Gene Namev-akt murine thymoma viral oncogene homolog 1
Gene SymbolAKT1
SynonymsAKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA;
Alternate namesRAC-alpha serine/threonine-protein kinase; AKT1m; PKB alpha; RAC-PK-alpha; proto-oncogene c-Akt; protein kinase B alpha; rac protein kinase alpha;
Chromosome14
Map Location14q32.32
EC Number2.7.11.1
SummaryThe serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
OrthologsView orthologs and multiple alignments for AKT1

Proteins

RAC-alpha serine/threonine-protein kinase
Refseq ID:NP_005154
Protein GI:62241011
UniProt ID:P31749
mRNA ID:NM_005163
Length:480
RefSeq Status:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWT
TAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENR
VLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAK
EIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
 
RAC-alpha serine/threonine-protein kinase
Refseq ID:NP_001014432
Protein GI:62241015
UniProt ID:P31749
mRNA ID:NM_001014432
Length:480
RefSeq Status:
Protein sequence is identical to GI:62241011 (mRNA isoform)
 
RAC-alpha serine/threonine-protein kinase
Refseq ID:NP_001014431
Protein GI:62241013
UniProt ID:P31749
mRNA ID:NM_001014431
Length:480
RefSeq Status:
Protein sequence is identical to GI:62241011 (mRNA isoform)