MitoProteome Database

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MT000021

Gene Information

Entrez Gene ID207
Gene Namev-akt murine thymoma viral oncogene homolog 1
Gene SymbolAKT1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005911 IEA:EnsemblCcell-cell junction
GO:0036064 IEA:EnsemblCciliary basal body
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 IDA:UniProtKBCcytosol
GO:0015630 IDA:HPACmicrotubule cytoskeleton
GO:0005739 IEA:EnsemblCmitochondrion
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 IDA:UniProtKBCplasma membrane
GO:0005819 IEA:EnsemblCspindle
GO:0071889 IPI:UniProtKBF14-3-3 protein binding
GO:0005524 IDA:UniProtKBFATP binding
GO:0019899 ISS:BHF-UCLFenzyme binding
GO:0042802 IPI:IntActFidentical protein binding
GO:0016301 IDA:MGIFkinase activity
GO:0030235 IMP:BHF-UCLFnitric-oxide synthase regulator activity
GO:0005547 IDA:UniProtKBFphosphatidylinositol-3,4,5-trisphosphate binding
GO:0043325 IDA:UniProtKBFphosphatidylinositol-3,4-bisphosphate binding
GO:0004672 TAS:ProtIncFprotein kinase activity
GO:0004674 IDA:UniProtKBFprotein serine/threonine kinase activity
GO:0004712 IDA:MGIFprotein serine/threonine/tyrosine kinase activity
GO:0006924 IMP:MGIPactivation-induced cell death of T cells
GO:0007568 IEA:EnsemblPaging
GO:0042640 IEA:EnsemblPanagen
GO:0008637 IEA:EnsemblPapoptotic mitochondrial changes
GO:0006915 TAS:ReactomePapoptotic process
GO:0007596 TAS:ReactomePblood coagulation
GO:0030154 TAS:UniProtKBPcell differentiation
GO:0030030 IEA:EnsemblPcell projection organization
GO:0008283 TAS:UniProtKBPcell proliferation
GO:0006464 TAS:ProtIncPcellular protein modification process
GO:0071364 IEA:EnsemblPcellular response to epidermal growth factor stimulus
GO:0097011 IEA:EnsemblPcellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0071456 IEA:EnsemblPcellular response to hypoxia
GO:0032869 IMP:BHF-UCLPcellular response to insulin stimulus
GO:0071260 IEA:EnsemblPcellular response to mechanical stimulus
GO:0031018 TAS:ReactomePendocrine pancreas development
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0097194 IEA:EnsemblPexecution phase of apoptosis
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0010467 TAS:ReactomePgene expression
GO:0007281 IEA:EnsemblPgerm cell development
GO:0042593 IEA:EnsemblPglucose homeostasis
GO:0006006 IEA:UniProtKB-KWPglucose metabolic process
GO:0015758 IEA:EnsemblPglucose transport
GO:0005978 IEA:UniProtKB-KWPglycogen biosynthetic process
GO:0060709 IEA:EnsemblPglycogen cell differentiation involved in embryonic placenta development
GO:0007186 TAS:ProtIncPG-protein coupled receptor signaling pathway
GO:0030212 IEA:EnsemblPhyaluronan metabolic process
GO:0006954 IEA:EnsemblPinflammatory response
GO:0045087 TAS:ReactomePinnate immune response
GO:0048009 IMP:UniProtKBPinsulin-like growth factor receptor signaling pathway
GO:0008286 IMP:UniProtKBPinsulin receptor signaling pathway
GO:0035556 IDA:MGIPintracellular signal transduction
GO:0097193 TAS:ReactomePintrinsic apoptotic signaling pathway
GO:0060716 IEA:EnsemblPlabyrinthine layer blood vessel development
GO:0060644 TAS:UniProtKBPmammary gland epithelial cell differentiation
GO:0001893 IEA:EnsemblPmaternal placenta development
GO:0061024 TAS:ReactomePmembrane organization
GO:0016071 TAS:ReactomePmRNA metabolic process
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:0010507 IMP:BHF-UCLPnegative regulation of autophagy
GO:0045792 IEA:EnsemblPnegative regulation of cell size
GO:0043154 ISS:UniProtKBPnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010951 IMP:BHF-UCLPnegative regulation of endopeptidase activity
GO:2001240 TAS:BHF-UCLPnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0031999 IMP:BHF-UCLPnegative regulation of fatty acid beta-oxidation
GO:0046329 IEA:EnsemblPnegative regulation of JNK cascade
GO:1901215 NAS:ParkinsonsUK-UCLPnegative regulation of neuron death
GO:1902176 NAS:BHF-UCLPnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:0010748 IMP:BHF-UCLPnegative regulation of plasma membrane long-chain fatty acid transport
GO:0006469 IMP:BHF-UCLPnegative regulation of protein kinase activity
GO:0045861 IMP:BHF-UCLPnegative regulation of proteolysis
GO:0090201 ISS:UniProtKBPnegative regulation of release of cytochrome c from mitochondria
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0006809 TAS:ProtIncPnitric oxide biosynthetic process
GO:0046209 TAS:ReactomePnitric oxide metabolic process
GO:0001649 IEA:EnsemblPosteoblast differentiation
GO:0018105 IDA:UniProtKBPpeptidyl-serine phosphorylation
GO:0032287 IEA:EnsemblPperipheral nervous system myelin maintenance
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0016310 IDA:UniProtKBPphosphorylation
GO:0030168 TAS:ReactomePplatelet activation
GO:0043065 IEA:EnsemblPpositive regulation of apoptotic process
GO:0043536 IDA:DFLATPpositive regulation of blood vessel endothelial cell migration
GO:0030307 IDA:UniProtKBPpositive regulation of cell growth
GO:0032270 ISS:BHF-UCLPpositive regulation of cellular protein metabolic process
GO:0031659 IDA:BHF-UCLPpositive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0001938 IMP:UniProtKBPpositive regulation of endothelial cell proliferation
GO:0090004 IMP:BHF-UCLPpositive regulation of establishment of protein localization to plasma membrane
GO:0045600 IMP:BHF-UCLPpositive regulation of fat cell differentiation
GO:0046326 IMP:BHF-UCLPpositive regulation of glucose import
GO:0010907 IMP:BHF-UCLPpositive regulation of glucose metabolic process
GO:0045725 IMP:BHF-UCLPpositive regulation of glycogen biosynthetic process
GO:0046889 IMP:BHF-UCLPpositive regulation of lipid biosynthetic process
GO:0045429 IMP:BHF-UCLPpositive regulation of nitric oxide biosynthetic process
GO:0051000 IMP:BHF-UCLPpositive regulation of nitric-oxide synthase activity
GO:0033138 IDA:UniProtKBPpositive regulation of peptidyl-serine phosphorylation
GO:0032436 IEA:EnsemblPpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:1900740 TAS:ReactomePpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001934 IDA:BHF-UCLPpositive regulation of protein phosphorylation
GO:0051091 IDA:BHF-UCLPpositive regulation of sequence-specific DNA binding transcription factor activity
GO:0010765 IEA:EnsemblPpositive regulation of sodium ion transport
GO:0045944 IEA:EnsemblPpositive regulation of transcription from RNA polymerase II promoter
GO:0045907 IEA:EnsemblPpositive regulation of vasoconstriction
GO:0046777 TAS:UniProtKBPprotein autophosphorylation
GO:0030163 IEA:EnsemblPprotein catabolic process
GO:0000060 IMP:UniProtKBPprotein import into nucleus, translocation
GO:0043491 IEA:EnsemblPprotein kinase B signaling
GO:0006468 IDA:UniProtKBPprotein phosphorylation
GO:0016567 IEA:EnsemblPprotein ubiquitination
GO:1901976 TAS:UniProtKBPregulation of cell cycle checkpoint
GO:0030334 IMP:UniProtKBPregulation of cell migration
GO:0005979 IMP:BHF-UCLPregulation of glycogen biosynthetic process
GO:0010975 ISS:UniProtKBPregulation of neuron projection development
GO:0050999 TAS:ReactomePregulation of nitric-oxide synthase activity
GO:0006417 IEA:UniProtKB-KWPregulation of translation
GO:0034405 IMP:BHF-UCLPresponse to fluid shear stress
GO:0032094 IEA:EnsemblPresponse to food
GO:0009408 TAS:ProtIncPresponse to heat
GO:0070141 IDA:BHF-UCLPresponse to UV-A
GO:0016070 TAS:ReactomePRNA metabolic process
GO:0007165 TAS:UniProtKBPsignal transduction
GO:0044281 TAS:ReactomePsmall molecule metabolic process
GO:0051146 IEA:EnsemblPstriated muscle cell differentiation
GO:0031295 TAS:ReactomePT cell costimulation
GO:0006412 IEA:EnsemblPtranslation
KEGG Pathway Links
KEGG Pathway IDDescription
hsa05221Acute myeloid leukemia
ko05221Acute myeloid leukemia
hsa04920Adipocytokine signaling pathway
ko04920Adipocytokine signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
ko04261Adrenergic signaling in cardiomyocytes
hsa04152AMPK signaling pathway
ko04152AMPK signaling pathway
hsa04210Apoptosis
ko04210Apoptosis
hsa04662B cell receptor signaling pathway
ko04662B cell receptor signaling pathway
hsa04024cAMP signaling pathway
ko04024cAMP signaling pathway
hsa04973Carbohydrate digestion and absorption
ko04973Carbohydrate digestion and absorption
hsa04022cGMP-PKG signaling pathway
ko04022cGMP-PKG signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
ko05142Chagas disease (American trypanosomiasis)
hsa04062Chemokine signaling pathway
ko04062Chemokine signaling pathway
hsa04725Cholinergic synapse
hsa05220Chronic myeloid leukemia
ko05220Chronic myeloid leukemia
hsa05210Colorectal cancer
ko05210Colorectal cancer
hsa04728Dopaminergic synapse
ko04728Dopaminergic synapse
hsa05213Endometrial cancer
ko05213Endometrial cancer
hsa05169Epstein-Barr virus infection
ko05169Epstein-Barr virus infection
hsa04012ErbB signaling pathway
ko04012ErbB signaling pathway
hsa04915Estrogen signaling pathway
ko04915Estrogen signaling pathway
hsa04664Fc epsilon RI signaling pathway
ko04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
ko04666Fc gamma R-mediated phagocytosis
hsa04510Focal adhesion
ko04510Focal adhesion
hsa04068FoxO signaling pathway
hsa05214Glioma
ko05214Glioma
hsa05161Hepatitis B
hsa05160Hepatitis C
ko05160Hepatitis C
hsa04066HIF-1 signaling pathway
hsa05166HTLV-I infection
ko05166HTLV-I infection
hsa05164Influenza A
ko05164Influenza A
hsa04910Insulin signaling pathway
ko04910Insulin signaling pathway
hsa04630Jak-STAT signaling pathway
ko04630Jak-STAT signaling pathway
hsa04010MAPK signaling pathway
ko04010MAPK signaling pathway
hsa05162Measles
ko05162Measles
hsa05218Melanoma
ko05218Melanoma
hsa04150mTOR signaling pathway
ko04150mTOR signaling pathway
hsa04722Neurotrophin signaling pathway
ko04722Neurotrophin signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
ko04932Non-alcoholic fatty liver disease (NAFLD)
hsa05223Non-small cell lung cancer
ko05223Non-small cell lung cancer
hsa04380Osteoclast differentiation
ko04380Osteoclast differentiation
hsa05212Pancreatic cancer
ko05212Pancreatic cancer
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
ko04151PI3K-Akt signaling pathway
hsa04611Platelet activation
hsa04914Progesterone-mediated oocyte maturation
ko04914Progesterone-mediated oocyte maturation
hsa04917Prolactin signaling pathway
ko04917Prolactin signaling pathway
hsa05215Prostate cancer
ko05215Prostate cancer
hsa05205Proteoglycans in cancer
ko05205Proteoglycans in cancer
hsa04015Rap1 signaling pathway
ko04015Rap1 signaling pathway
hsa04014Ras signaling pathway
hsa05211Renal cell carcinoma
ko05211Renal cell carcinoma
hsa04550Signaling pathways regulating pluripotency of stem cells
ko04550Signaling pathways regulating pluripotency of stem cells
hsa05222Small cell lung cancer
ko05222Small cell lung cancer
hsa04660T cell receptor signaling pathway
ko04660T cell receptor signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04530Tight junction
ko04530Tight junction
hsa04668TNF signaling pathway
ko04668TNF signaling pathway
hsa04620Toll-like receptor signaling pathway
ko04620Toll-like receptor signaling pathway
hsa05145Toxoplasmosis
ko05145Toxoplasmosis
hsa05152Tuberculosis
ko05152Tuberculosis
hsa04370VEGF signaling pathway
ko04370VEGF signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_549Activation of BAD and translocation to mitochondria
REACT_697Activation of BH3-only proteins
REACT_75774Adaptive Immune System
REACT_13655AKT-mediated inactivation of FOXO1A
REACT_12564AKT phosphorylates targets in the cytosol
REACT_12442AKT phosphorylates targets in the nucleus
REACT_578Apoptosis
REACT_24915Butyrate Response Factor 1 (BRF1) destabilizes mRNA
REACT_19183CD28 co-stimulation
REACT_19358CD28 dependent PI3K/Akt signaling
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_19344Costimulation by the CD28 family
REACT_19405CTLA4 inhibitory signaling
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_200731deactivation of the beta-catenin transactivating complex
REACT_111045Developmental Biology
REACT_116125Disease
REACT_115662Downregulation of ERBB2:ERBB3 signaling
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_12477eNOS activation
REACT_12389eNOS activation and regulation
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_71Gene Expression
REACT_19184GPCR downstream signaling
REACT_19388G-protein beta:gamma signalling
REACT_1695GPVI-mediated activation cascade
REACT_604Hemostasis
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_15523Integrin alphaIIb beta3 signaling
REACT_964Intrinsic Pathway for Apoptosis
REACT_25042KSRP destabilizes mRNA
REACT_11123Membrane Trafficking
REACT_111217Metabolism
REACT_12508Metabolism of nitric oxide
REACT_228096misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
REACT_12447Negative regulation of the PI3K/AKT network
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_798Platelet activation, signaling and aggregation
REACT_278Platelet Aggregation (Plug Formation)
REACT_13698Regulation of beta-cell development
REACT_13819Regulation of gene expression in beta cells
REACT_24994Regulation of mRNA stability by proteins that bind AU-rich elements
REACT_228188RNF mutants show enhanced WNT signaling and proliferation
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_14797Signaling by GPCR
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_12529Signaling by VEGF
REACT_11045Signaling by Wnt
REACT_228331Signaling by WNT in cancer
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_200777TCF dependent signaling in response to WNT
REACT_111176Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
REACT_147867Translocation of GLUT4 to the plasma membrane
REACT_228166VEGFA-VEGFR2 Pathway
REACT_228016VEGFR2 mediated vascular permeability
REACT_228279XAV939 inhibits tankyrase, stabilizing AXIN