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MT000027

UniProt Annotations

Entry Information

Gene Name	aldehyde dehydrogenase 1 family, member B1
Protein Entry	AL1B1_HUMAN
UniProt ID	P30837
Species	Human

Comments

Comment type	Description
Catalytic Activity	An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
Function	ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Similarity	Belongs to the aldehyde dehydrogenase family. {ECO:0000305}.
Subcellular Location	Mitochondrion matrix.
Subunit	Homotetramer. {ECO:0000250}.
Tissue Specificity	Liver, testis and to a lesser extent in brain.