MitoProteome Database

MT000039

Record overview

MITO ID	MT000039
Gene ID	328
Species	Homo sapiens (Human)
Gene Name	APEX nuclease (multifunctional DNA repair enzyme) 1
Gene Symbol	APEX1
Synonyms	APE; APX; APE1; APEN; APEX; HAP1; REF1;
Alternate names	DNA-(apurinic or apyrimidinic site) lyase; AP lyase; protein REF-1; redox factor-1; AP endonuclease class I; apurinic-apyrimidinic endonuclease 1; apurinic/apyrimidinic (abasic) endonuclease; deoxyribonuclease (apurinic or apyrimidinic);
Chromosome	14
Map Location	14q11.2
EC Number	3.1.-.-
Summary	Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for APEX1

Proteins

DNA-(apurinic or apyrimidinic site) lyase

Refseq ID:	NP_001632
Protein GI:	18375501
UniProt ID:	P27695
mRNA ID:	NM_001641
Length:	318
RefSeq Status:

`MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCS ENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLA SRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI RSKALGSDHCPITLYLAL`

N
mat_peptide: 32..318
product: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial (By similarity)
inference: non-experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P27695.2)
calculated_mol_wt: 32245
peptide sequence: 
KNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGV
GLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAG
FTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

DNA-(apurinic or apyrimidinic site) lyase

Refseq ID:	NP_542380
Protein GI:	18375505
UniProt ID:	P27695
mRNA ID:	NM_080649
Length:	318
RefSeq Status:

Protein sequence is identical to GI:18375501 (mRNA isoform)

N
mat_peptide: 32..318
product: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial (By similarity)
inference: non-experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P27695.2)
calculated_mol_wt: 32245
peptide sequence: 
KNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGV
GLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAG
FTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

mat_peptide: 32..318
product: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial (By similarity)
inference: non-experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P27695.2)
calculated_mol_wt: 32245
peptide sequence: 
KNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGV
GLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAG
FTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

mat_peptide: 32..318
product: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial (By similarity)
inference: non-experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P27695.2)
calculated_mol_wt: 32245
peptide sequence: 
KNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGV
GLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAG
FTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

mat_peptide: 32..318
product: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial (By similarity)
inference: non-experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P27695.2)
calculated_mol_wt: 32245
peptide sequence: 
KNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGV
GLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAG
FTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

DNA-(apurinic or apyrimidinic site) lyase

Refseq ID:	NP_542379
Protein GI:	18375503
UniProt ID:	P27695
mRNA ID:	NM_080648
Length:	318
RefSeq Status:

Protein sequence is identical to GI:18375501 (mRNA isoform)

N
mat_peptide: 32..318
product: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial (By similarity)
inference: non-experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P27695.2)
calculated_mol_wt: 32245
peptide sequence: 
KNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGV
GLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAG
FTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

mat_peptide: 32..318
product: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial (By similarity)
inference: non-experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P27695.2)
calculated_mol_wt: 32245
peptide sequence: 
KNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGV
GLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAG
FTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

mat_peptide: 32..318
product: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial (By similarity)
inference: non-experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P27695.2)
calculated_mol_wt: 32245
peptide sequence: 
KNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGV
GLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAG
FTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

DNA-(apurinic or apyrimidinic site) lyase

Refseq ID:	NP_001231178
Protein GI:	346644849
UniProt ID:	P27695
mRNA ID:	NM_001244249
Length:	318
RefSeq Status:

Protein sequence is identical to GI:18375501 (mRNA isoform)

N
mat_peptide: 32..318
product: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial (By similarity)
inference: non-experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P27695.2)
calculated_mol_wt: 32245
peptide sequence: 
KNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGV
GLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAG
FTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL

mat_peptide: 32..318
product: DNA-(apurinic or apyrimidinic site) lyase, mitochondrial (By similarity)
inference: non-experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P27695.2)
calculated_mol_wt: 32245
peptide sequence: 
KNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGV
GLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAG
FTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL