MitoProteome Database

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MT000039

Gene Information

Entrez Gene ID328
Gene NameAPEX nuclease (multifunctional DNA repair enzyme) 1
Gene SymbolAPEX1
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005813 IDA:HPACcentrosome
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005783 TAS:UniProtKBCendoplasmic reticulum
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0016607 IDA:UniProtKBCnuclear speck
GO:0005730 IDA:UniProtKBCnucleolus
GO:0005654 IDA:UniProtKBCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0048471 IDA:UniProtKBCperinuclear region of cytoplasm
GO:0005840 TAS:UniProtKBCribosome
GO:0005667 IEA:EnsemblCtranscription factor complex
GO:0008408 IDA:UniProtKBF3'-5' exonuclease activity
GO:0031490 IDA:UniProtKBFchromatin DNA binding
GO:0003684 IDA:UniProtKBFdamaged DNA binding
GO:0003906 IDA:UniProtKBFDNA-(apurinic or apyrimidinic site) lyase activity
GO:0003677 IDA:UniProtKBFDNA binding
GO:0008311 IBA:RefGenomeFdouble-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0004520 TAS:ProtIncFendodeoxyribonuclease activity
GO:0004519 IDA:MGIFendonuclease activity
GO:0046872 IDA:UniProtKBFmetal ion binding
GO:0016491 IDA:UniProtKBFoxidoreductase activity
GO:0004528 TAS:UniProtKBFphosphodiesterase I activity
GO:0008081 IDA:MGIFphosphoric diester hydrolase activity
GO:0044822 IDA:UniProtKBFpoly(A) RNA binding
GO:0004523 TAS:UniProtKBFRNA-DNA hybrid ribonuclease activity
GO:0016890 IDA:UniProtKBFsite-specific endodeoxyribonuclease activity, specific for altered base
GO:0003713 IDA:UniProtKBFtranscription coactivator activity
GO:0003714 TAS:ProtIncFtranscription corepressor activity
GO:0004844 TAS:ProtIncFuracil DNA N-glycosylase activity
GO:0007568 IEA:EnsemblPaging
GO:0006284 IBA:RefGenomePbase-excision repair
GO:0045454 IEA:EnsemblPcell redox homeostasis
GO:0071320 IEA:EnsemblPcellular response to cAMP
GO:0070301 IEA:EnsemblPcellular response to hydrogen peroxide
GO:0071375 IEA:EnsemblPcellular response to peptide hormone stimulus
GO:0000737 IDA:GOCPDNA catabolic process, endonucleolytic
GO:0000738 IBA:GOCPDNA catabolic process, exonucleolytic
GO:0080111 IDA:UniProtKBPDNA demethylation
GO:0006310 IEA:UniProtKB-KWPDNA recombination
GO:0006281 IDA:UniProtKBPDNA repair
GO:0014912 IEA:EnsemblPnegative regulation of smooth muscle cell migration
GO:0090305 IDA:GOCPnucleic acid phosphodiester bond hydrolysis
GO:0055114 IDA:GOCPoxidation-reduction process
GO:0045739 IDA:UniProtKBPpositive regulation of DNA repair
GO:1900087 IEA:EnsemblPpositive regulation of G1/S transition of mitotic cell cycle
GO:0043488 IMP:UniProtKBPregulation of mRNA stability
GO:0006355 IEA:UniProtKB-KWPregulation of transcription, DNA-templated
GO:0042493 IEA:EnsemblPresponse to drug
GO:0090502 TAS:GOCPRNA phosphodiester bond hydrolysis, endonucleolytic
GO:0006351 IEA:UniProtKB-KWPtranscription, DNA-templated
KEGG Pathway Links
KEGG Pathway IDDescription
hsa03410Base excision repair
ko03410Base excision repair
hsa_M00296BER complex
M00296BER complex
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_1104Base Excision Repair
REACT_1357Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
REACT_1064Displacement of DNA glycosylase by APE1
REACT_216DNA Repair
REACT_2192Removal of DNA patch containing abasic residue
REACT_1893Resolution of Abasic Sites (AP sites)
REACT_1128Resolution of AP sites via the multiple-nucleotide patch replacement pathway
REACT_933Resolution of AP sites via the single-nucleotide replacement pathway