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MT000040

UniProt Annotations

Entry Information

Gene Name	A-Raf proto-oncogene, serine/threonine kinase
Protein Entry	ARAF_HUMAN
UniProt ID	P10398
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P10398-1; Sequence=Displayed; Name=2; Synonyms=DA-Raf1; IsoId=P10398-2; Sequence=VSP_045609, VSP_045610; Note=Has a wider tissue distribution than isoform 1, and acts as dominant-negative antagonist.;
Catalytic Activity	ATP + a protein = ADP + a phosphoprotein.
Cofactor	Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
Function	Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. {ECO:0000269\|PubMed:22609986}.
Function	Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. {ECO:0000269\|PubMed:22609986}.
Interaction	P00966:ASS1; NbExp=4; IntAct=EBI-365961, EBI-536842; P15056:BRAF; NbExp=2; IntAct=EBI-365961, EBI-365980; Q9UNS2:COPS3; NbExp=3; IntAct=EBI-365961, EBI-350590; P31327:CPS1; NbExp=3; IntAct=EBI-365961, EBI-536811; Q12805:EFEMP1; NbExp=3; IntAct=EBI-365961, EBI-536772; P08238:HSP90AB1; NbExp=6; IntAct=EBI-365961, EBI-352572; O43187:IRAK2; NbExp=2; IntAct=EBI-365961, EBI-447733; Q92985:IRF7; NbExp=2; IntAct=EBI-365961, EBI-968267; P36507:MAP2K2; NbExp=4; IntAct=EBI-365961, EBI-1056930; Q8IXH7:NELFCD; NbExp=5; IntAct=EBI-365961, EBI-536725; O95848:NUDT14; NbExp=3; IntAct=EBI-365961, EBI-536866; Q96KB5:PBK; NbExp=3; IntAct=EBI-365961, EBI-536853; P14618:PKM; NbExp=2; IntAct=EBI-365961, EBI-353408; O94906:PRPF6; NbExp=4; IntAct=EBI-365961, EBI-536755; P53611:RABGGTB; NbExp=3; IntAct=EBI-365961, EBI-536715; P62070:RRAS2; NbExp=3; IntAct=EBI-365961, EBI-491037; O43615:TIMM44; NbExp=3; IntAct=EBI-365961, EBI-861737; Q3ZCQ8:TIMM50; NbExp=3; IntAct=EBI-365961, EBI-355175; P58753:TIRAP; NbExp=2; IntAct=EBI-365961, EBI-528644; P63104:YWHAZ; NbExp=3; IntAct=EBI-365961, EBI-347088;
Similarity	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. {ECO:0000305}.
Similarity	Contains 1 phorbol-ester/DAG-type zinc finger. {ECO:0000255\|PROSITE-ProRule:PRU00226}.
Similarity	Contains 1 protein kinase domain. {ECO:0000255\|PROSITE-ProRule:PRU00159}.
Similarity	Contains 1 RBD (Ras-binding) domain. {ECO:0000255\|PROSITE-ProRule:PRU00262}.
Subunit	Interacts with TH1L/NELFD. {ECO:0000269\|PubMed:11952167}.
Tissue Specificity	Predominantly in urogenital tissues.