MitoProteome Database

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MT000052

Record overview

MITO IDMT000052
Gene ID509
SpeciesHomo sapiens (Human)
Gene NameATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
Gene SymbolATP5C1
SynonymsATP5C; ATP5CL1;
Alternate namesATP synthase subunit gamma, mitochondrial; F-ATPase gamma subunit; ATP synthase gamma chain, mitochondrial; mitochondrial ATP synthase, gamma subunit 1;
Chromosome10
Map Location10p15.1
SummaryThis gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ATP5C1

Proteins

ATP synthase subunit gamma, mitochondrial isoform H (heart) precursor
Refseq ID:NP_005165
Protein GI:4885079
UniProt ID:P36542
mRNA ID:NM_005174
Length:297
RefSeq Status:
MFSRAGVAGLSAWTLQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARIYGLGSLALYEKADIKGPEDKKKHLLIGVSSDR
GLCGAIHSSIAKQMKSEVATLTAAGKEVMLVGIGDKIRGILYRTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEFDEGSIIFNKFRSVISYKTEE
KPIFSLNTVASADSMSIYDDIDADVLQNYQEYNLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAAL
 
N
transit_peptide: 1..25
calculated_mol_wt: 2848
peptide sequence: 
MFSRAGVAGLSAWTLQPQWIQVRNM

mat_peptide: 26..297
product: ATP synthase subunit gamma, mitochondrial isoform H (heart)
calculated_mol_wt: 30051
peptide sequence: 
ATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARIYGLGSLALYEKADIKGPEDKKKHLLIGVSSDRGLCGAIHSSIAKQMKSEVATLTAAG
KEVMLVGIGDKIRGILYRTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEFDEGSIIFNKFRSVISYKTEEKPIFSLNTVASADSMSIYDDIDADV
LQNYQEYNLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAAL
 
ATP synthase subunit gamma, mitochondrial isoform L (liver) precursor
Refseq ID:NP_001001973
Protein GI:50345988
UniProt ID:P36542
mRNA ID:NM_001001973
Length:298
RefSeq Status:
MFSRAGVAGLSAWTLQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARIYGLGSLALYEKADIKGPEDKKKHLLIGVSSDR
GLCGAIHSSIAKQMKSEVATLTAAGKEVMLVGIGDKIRGILYRTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEFDEGSIIFNKFRSVISYKTEE
KPIFSLNTVASADSMSIYDDIDADVLQNYQEYNLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
 
N
transit_peptide: 1..25
calculated_mol_wt: 2848
peptide sequence: 
MFSRAGVAGLSAWTLQPQWIQVRNM

mat_peptide: 26..297
product: ATP synthase subunit gamma, mitochondrial isoform H (heart)
calculated_mol_wt: 30051
peptide sequence: 
ATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARIYGLGSLALYEKADIKGPEDKKKHLLIGVSSDRGLCGAIHSSIAKQMKSEVATLTAAG
KEVMLVGIGDKIRGILYRTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEFDEGSIIFNKFRSVISYKTEEKPIFSLNTVASADSMSIYDDIDADV
LQNYQEYNLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAAL

transit_peptide: 1..25
calculated_mol_wt: 2848
peptide sequence: 
MFSRAGVAGLSAWTLQPQWIQVRNM

mat_peptide: 26..298
product: ATP synthase subunit gamma, mitochondrial isoform L (liver)
calculated_mol_wt: 30166
peptide sequence: 
ATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARIYGLGSLALYEKADIKGPEDKKKHLLIGVSSDRGLCGAIHSSIAKQMKSEVATLTAAG
KEVMLVGIGDKIRGILYRTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEFDEGSIIFNKFRSVISYKTEEKPIFSLNTVASADSMSIYDDIDADV
LQNYQEYNLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD