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MitoProteome Human Mitochondrial Protein Database
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Related Proteins
MT000058
UniProt Annotations
Entry Information
Gene Name
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
Protein Entry
UniProt ID
Species
Human
Comments
Comment type
Description
Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
Miscellaneous
There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).
Similarity
Belongs to the ATPase C chain family. {ECO:0000305}.
Subcellular Location
Mitochondrion membrane; Multi-pass membrane protein.
Subunit
F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
MitoProteome Human Mitochondrial Protein Database
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