MitoProteome Database

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MT000061

UniProt Annotations

Entry Information

Gene Name	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
Protein Entry	VATA_HUMAN
UniProt ID	P38606
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P38606-1; Sequence=Displayed; Name=2; IsoId=P38606-2; Sequence=VSP_056408; Note=No experimental confirmation available.;
Catalytic Activity	ATP + H(2)O + H(+)(In) = ADP + phosphate + H(+)(Out).
Function	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Similarity	Belongs to the ATPase alpha/beta chains family. {ECO:0000305}.
Subunit	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (main components: subunits A, B, C, D, E, and F) attached to an integral membrane V0 proton pore complex (main component: the proteolipid protein).
Tissue Specificity	Present in all tissues analyzed.