MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MT000062

Record overview

MITO IDMT000062
Gene ID529
SpeciesHomo sapiens (Human)
Gene NameATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
Gene SymbolATP6V1E1
SynonymsP31; Vma4; ATP6E; ATP6E2; ATP6V1E;
Alternate namesV-type proton ATPase subunit E 1; V-ATPase, subunit E; V-ATPase subunit E 1; V-ATPase 31 kDa subunit; vacuolar proton pump subunit E 1; H+-transporting ATP synthase chain E, vacuolar; H(+)-transporting two-sector ATPase, 31kDa subunit;
Chromosome22
Map Location22q11.1
SummaryThis gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ATP6V1E1

Proteins

V-type proton ATPase subunit E 1 isoform a
Refseq ID:NP_001687
Protein GI:4502317
UniProt ID:P36543
mRNA ID:NM_001696
Length:226
RefSeq Status:
MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQ
RLSKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRL
DLIAQQMMPEVRGALFGANANRKFLD
 
V-type proton ATPase subunit E 1 isoform b
Refseq ID:NP_001034455
Protein GI:87159816
UniProt ID:P36543
mRNA ID:NM_001039366
Length:204
RefSeq Status:
MALSDADVQKQAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQ
GLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRGALFGANANR
KFLD
 
V-type proton ATPase subunit E 1 isoform c
Refseq ID:NP_001034456
Protein GI:87159818
UniProt ID:P36543
mRNA ID:NM_001039367
Length:196
RefSeq Status:
MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITGLYQLLEP
RMIVRCRKQDFPLVKAAVQKAIPMYKIATKNDVDVQIDQESYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRGALFGANANRKFLD