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MT000062

UniProt Annotations

Entry Information

Gene Name	ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
Protein Entry	VATE1_HUMAN
UniProt ID	P36543
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P36543-1; Sequence=Displayed; Name=2; IsoId=P36543-2; Sequence=VSP_042925; Note=No experimental confirmation available.; Name=3; IsoId=P36543-3; Sequence=VSP_044589;
Function	Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Similarity	Belongs to the V-ATPase E subunit family. {ECO:0000305}.
Subunit	V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2 (By similarity). Interacts with ALDOC. Interacts with RAB11B. {ECO:0000250, ECO:0000269\|PubMed:11399750, ECO:0000269\|PubMed:20717956}.
Tissue Specificity	Ubiquitous. {ECO:0000269\|PubMed:12036578}.