MitoProteome Database

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MT000064

UniProt Annotations

Entry Information

Gene Name	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
Protein Entry	ATPO_HUMAN
UniProt ID	P48047
Species	Human

Comments

Comment type	Description
Function	Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Ptm	Acetylation at Lys-162 decreases ATP production. Deacetylated by SIRT3. {ECO:0000269\|PubMed:19608861, ECO:0000269\|Ref.11}.
Similarity	Belongs to the ATPase delta chain family. {ECO:0000305}.
Subcellular Location	Mitochondrion {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}.
Subunit	F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity). {ECO:0000250}.