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MT000067

UniProt Annotations

Entry Information

Gene Name	arginine vasopressin
Protein Entry	NEU2_HUMAN
UniProt ID	P01185
Species	Human

Comments

Comment type	Description
Disease	Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]: A disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopressin deficiency during childhood. {ECO:0000269\|PubMed:10369876, ECO:0000269\|PubMed:10487710, ECO:0000269\|PubMed:10677561, ECO:0000269\|PubMed:11017955, ECO:0000269\|PubMed:11150885, ECO:0000269\|PubMed:11161827, ECO:0000269\|PubMed:11443218, ECO:0000269\|PubMed:11748489, ECO:0000269\|PubMed:11980620, ECO:0000269\|PubMed:12012274, ECO:0000269\|PubMed:12107248, ECO:0000269\|PubMed:12359138, ECO:0000269\|PubMed:12519420, ECO:0000269\|PubMed:12931042, ECO:0000269\|PubMed:14510916, ECO:0000269\|PubMed:14673472, ECO:0000269\|PubMed:15538939, ECO:0000269\|PubMed:1740104, ECO:0000269\|PubMed:7714110, ECO:0000269\|PubMed:8045958, ECO:0000269\|PubMed:8103767, ECO:0000269\|PubMed:8370682, ECO:0000269\|PubMed:8514868, ECO:0000269\|PubMed:8554046, ECO:0000269\|PubMed:9360520, ECO:0000269\|PubMed:9580132, ECO:0000269\|PubMed:9814475}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Function	Neurophysin 2 specifically binds vasopressin.
Function	Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.
Similarity	Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
Subcellular Location	Secreted.
Web Resource	Name=Wikipedia; Note=Vasopressin entry; URL="http://en.wikipedia.org/wiki/Vasopressin";