MitoProteome Database

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MT000068

Gene Information

Entrez Gene ID572
Gene NameBCL2-associated agonist of cell death
Gene SymbolBAD
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IDA:UniProtKBCcytosol
GO:0005741 IDA:UniProtKBCmitochondrial outer membrane
GO:0005739 IDA:HPACmitochondrion
GO:0008656 IDA:UniProtKBFcysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008289 IDA:UniProtKBFlipid binding
GO:0005543 IMP:UniProtKBFphospholipid binding
GO:0019901 IPI:UniProtKBFprotein kinase binding
GO:0097202 IDA:BHF-UCLPactivation of cysteine-type endopeptidase activity
GO:0006919 ISS:UniProtKBPactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0046031 ISS:UniProtKBPADP metabolic process
GO:0006915 IDA:UniProtKBPapoptotic process
GO:0097190 TAS:ReactomePapoptotic signaling pathway
GO:0046034 ISS:UniProtKBPATP metabolic process
GO:0060154 IEA:EnsemblPcellular process regulating host cell cycle in response to virus
GO:0071247 IEA:EnsemblPcellular response to chromate
GO:0071456 IEP:UniProtKBPcellular response to hypoxia
GO:0071396 IEA:EnsemblPcellular response to lipid
GO:0071260 IEP:UniProtKBPcellular response to mechanical stimulus
GO:0071316 IDA:UniProtKBPcellular response to nicotine
GO:0019221 IEA:EnsemblPcytokine-mediated signaling pathway
GO:0007173 TAS:ReactomePepidermal growth factor receptor signaling pathway
GO:0097191 IMP:UniProtKBPextrinsic apoptotic signaling pathway
GO:0097192 IEA:EnsemblPextrinsic apoptotic signaling pathway in absence of ligand
GO:0008625 IEA:EnsemblPextrinsic apoptotic signaling pathway via death domain receptors
GO:0038095 TAS:ReactomePFc-epsilon receptor signaling pathway
GO:0008543 TAS:ReactomePfibroblast growth factor receptor signaling pathway
GO:0006007 IEA:EnsemblPglucose catabolic process
GO:0042593 ISS:UniProtKBPglucose homeostasis
GO:0045087 TAS:ReactomePinnate immune response
GO:0097193 IMP:UniProtKBPintrinsic apoptotic signaling pathway
GO:0008630 IEA:EnsemblPintrinsic apoptotic signaling pathway in response to DNA damage
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0048015 TAS:ReactomePphosphatidylinositol-mediated signaling
GO:0046931 IDA:UniProtKBPpore complex assembly
GO:0043065 IDA:UniProtKBPpositive regulation of apoptotic process
GO:0060139 IEA:EnsemblPpositive regulation of apoptotic process by virus
GO:0010508 TAS:UniProtKBPpositive regulation of autophagy
GO:0045579 IEA:EnsemblPpositive regulation of B cell differentiation
GO:0043280 IDA:UniProtKBPpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050679 IMP:UniProtKBPpositive regulation of epithelial cell proliferation
GO:0033133 ISS:UniProtKBPpositive regulation of glucokinase activity
GO:0032024 ISS:UniProtKBPpositive regulation of insulin secretion
GO:0035774 IEA:EnsemblPpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:2001244 TAS:ReactomePpositive regulation of intrinsic apoptotic signaling pathway
GO:0010918 ISS:UniProtKBPpositive regulation of mitochondrial membrane potential
GO:1901216 IEA:EnsemblPpositive regulation of neuron death
GO:1900740 TAS:ReactomePpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0045862 IDA:BHF-UCLPpositive regulation of proteolysis
GO:0090200 IMP:UniProtKBPpositive regulation of release of cytochrome c from mitochondria
GO:0045582 IEA:EnsemblPpositive regulation of T cell differentiation
GO:2000078 ISS:UniProtKBPpositive regulation of type B pancreatic cell development
GO:0046902 IMP:UniProtKBPregulation of mitochondrial membrane permeability
GO:0001836 IEA:EnsemblPrelease of cytochrome c from mitochondria
GO:0043200 IEA:EnsemblPresponse to amino acid
GO:0051592 IEA:EnsemblPresponse to calcium ion
GO:0042493 IEA:EnsemblPresponse to drug
GO:0032355 IEA:EnsemblPresponse to estradiol
GO:0045471 IEA:EnsemblPresponse to ethanol
GO:0051384 IEA:EnsemblPresponse to glucocorticoid
GO:0009749 IEA:EnsemblPresponse to glucose
GO:0042542 IEA:EnsemblPresponse to hydrogen peroxide
GO:0034201 IEA:EnsemblPresponse to oleic acid
GO:0032570 IEA:EnsemblPresponse to progesterone
GO:0033574 IEA:EnsemblPresponse to testosterone
GO:0019050 IEA:EnsemblPsuppression by virus of host apoptotic process
GO:0044342 ISS:UniProtKBPtype B pancreatic cell proliferation
KEGG Pathway Links
KEGG Pathway IDDescription
hsa05221Acute myeloid leukemia
ko05221Acute myeloid leukemia
hsa05010Alzheimer's disease
ko05010Alzheimer's disease
hsa05014Amyotrophic lateral sclerosis (ALS)
ko05014Amyotrophic lateral sclerosis (ALS)
hsa04210Apoptosis
ko04210Apoptosis
hsa04024cAMP signaling pathway
ko04024cAMP signaling pathway
hsa04022cGMP-PKG signaling pathway
ko04022cGMP-PKG signaling pathway
hsa05220Chronic myeloid leukemia
ko05220Chronic myeloid leukemia
hsa05210Colorectal cancer
ko05210Colorectal cancer
hsa05213Endometrial cancer
ko05213Endometrial cancer
hsa04012ErbB signaling pathway
ko04012ErbB signaling pathway
hsa04510Focal adhesion
ko04510Focal adhesion
hsa05161Hepatitis B
hsa05160Hepatitis C
ko05160Hepatitis C
hsa04910Insulin signaling pathway
ko04910Insulin signaling pathway
hsa05218Melanoma
ko05218Melanoma
hsa04722Neurotrophin signaling pathway
ko04722Neurotrophin signaling pathway
hsa05223Non-small cell lung cancer
ko05223Non-small cell lung cancer
hsa05212Pancreatic cancer
ko05212Pancreatic cancer
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
ko04151PI3K-Akt signaling pathway
hsa05215Prostate cancer
ko05215Prostate cancer
hsa04014Ras signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa05145Toxoplasmosis
ko05145Toxoplasmosis
hsa05152Tuberculosis
ko05152Tuberculosis
hsa04370VEGF signaling pathway
ko04370VEGF signaling pathway
hsa05203Viral carcinogenesis
ko05203Viral carcinogenesis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_549Activation of BAD and translocation to mitochondria
REACT_697Activation of BH3-only proteins
REACT_75774Adaptive Immune System
REACT_12564AKT phosphorylates targets in the cytosol
REACT_578Apoptosis
REACT_330BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_116125Disease
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_21272Downstream signaling of activated FGFR
REACT_17025Downstream signal transduction
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_12578GAB1 signalosome
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_964Intrinsic Pathway for Apoptosis
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_13638NRAGE signals death through JNK
REACT_13776p75 NTR receptor-mediated signalling
REACT_12464PI3K/AKT activation
REACT_147723PI3K/AKT Signaling in Cancer
REACT_21270PI-3K cascade
REACT_116008PI3K events in ERBB2 signaling
REACT_115961PI3K events in ERBB4 signaling
REACT_75829PIP3 activates AKT signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
REACT_9417Signaling by EGFR
REACT_115871Signaling by EGFR in Cancer
REACT_115755Signaling by ERBB2
REACT_115596Signaling by ERBB4
REACT_9470Signaling by FGFR
REACT_120736Signaling by FGFR in disease
REACT_16888Signaling by PDGF
REACT_111040Signaling by SCF-KIT
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_11061Signalling by NGF
REACT_111102Signal Transduction