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MT000069

Record overview

MITO IDMT000069
Gene ID573
SpeciesHomo sapiens (Human)
Gene NameBCL2-associated athanogene
Gene SymbolBAG1
SynonymsHAP; BAG-1; RAP46;
Alternate namesBAG family molecular chaperone regulator 1; Bcl-2-binding protein; receptor-associated protein, 46-KD; Bcl-2 associating athanogene-1 protein; glucocortoid receptor-associated protein RAP46;
Chromosome9
Map Location9p12
SummaryThe oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]
OrthologsView orthologs and multiple alignments for BAG1

Proteins

BAG family molecular chaperone regulator 1 isoform BAG-1L
Refseq ID:NP_004314
Protein GI:288915525
UniProt ID:Q99933
mRNA ID:NM_004323
Length:345
RefSeq Status:
MAQRGGARRPRGDRERLGSRLRALRPGREPRQSEPPAQRGPPPSRRPPARSTASGHDRPTRGAAAGARRPRMKKKTRRRSTRSEELTRSEELTLSEEATW
SEEATQSEEATQGEEMNRSQEVTRDEESTRSEEVTREEMAAAGLTVTVTHSNEKHDLHVTSQQGSSEPVVQDLAQVVEEVIGVPQSFQKLIFKGKSLKEM
ETPLSALGIQDGCRVMLIGKKNSPQEEVELKKLKHLEKSVEKIADQLEELNKELTGIQQGFLPKDLQAEALCKLDRRVKATIEQFMKILEEIDTLILPEN
FKDSRLKRKGLVKKVQAFLAECDTVEQNICQETERLQSTNFALAE
 
BAG family molecular chaperone regulator 1 isoform BAG-1S
Refseq ID:NP_001165886
Protein GI:288915527
UniProt ID:Q99933
mRNA ID:NM_001172415
Length:230
RefSeq Status:
MNRSQEVTRDEESTRSEEVTREEMAAAGLTVTVTHSNEKHDLHVTSQQGSSEPVVQDLAQVVEEVIGVPQSFQKLIFKGKSLKEMETPLSALGIQDGCRV
MLIGKKNSPQEEVELKKLKHLEKSVEKIADQLEELNKELTGIQQGFLPKDLQAEALCKLDRRVKATIEQFMKILEEIDTLILPENFKDSRLKRKGLVKKV
QAFLAECDTVEQNICQETERLQSTNFALAE