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MT000069

UniProt Annotations

Entry Information

Gene Name	BCL2-associated athanogene
Protein Entry	BAG1_HUMAN
UniProt ID	Q99933
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing, Alternative initiation; Named isoforms=4; Name=1; Synonyms=BAG-1L, p50; IsoId=Q99933-1; Sequence=Displayed; Name=2; Synonyms=BAG1V, HAPV; IsoId=Q99933-2; Sequence=VSP_000453; Note=Produced by alternative splicing.; Name=3; Synonyms=BAG-1M, RAP46; IsoId=Q99933-3; Sequence=VSP_038395; Note=Produced by alternative initiation at Met-72 of isoform 1.; Name=4; Synonyms=BAG-1, p32; IsoId=Q99933-4; Sequence=VSP_038394; Note=Produced by alternative initiation at Met-116 of isoform 1.;
Function	Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. {ECO:0000269\|PubMed:12724406, ECO:0000269\|PubMed:9305631, ECO:0000269\|PubMed:9873016}.
Induction	Up-regulated during differentiation of bladder epithelial cells and down-regulated during differentiation of prostate epithelium. {ECO:0000269\|PubMed:9679980}.
Interaction	Q53FC7:-; NbExp=2; IntAct=EBI-1030678, EBI-9356749; Q96BE0:-; NbExp=2; IntAct=EBI-1030678, EBI-9356686; P11142:HSPA8; NbExp=10; IntAct=EBI-1030678, EBI-351896; Q13200:PSMD2; NbExp=2; IntAct=EBI-1030678, EBI-357648; Q9UNE7:STUB1; NbExp=2; IntAct=EBI-1030678, EBI-357085;
Ptm	Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. {ECO:0000305}.
Sequence Caution	Sequence=AAD11467.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD25045.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD96469.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAA84624.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAH72516.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72518.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72741.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH72742.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW58515.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Contains 1 BAG domain. {ECO:0000255\|PROSITE- ProRule:PRU00369}.
Similarity	Contains 1 ubiquitin-like domain. {ECO:0000255\|PROSITE-ProRule:PRU00214}.
Subcellular Location	Isoform 1: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus.
Subcellular Location	Isoform 2: Cytoplasm. Nucleus. Note=Isoform 2 localizes to the cytoplasm and shuttles into the nucleus in response to heat shock.
Subcellular Location	Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria.
Subunit	Homodimer. Forms a heteromeric complex with HSP70/HSC70. Binds to the ATPase domain of HSP/HSC70 chaperones. Isoform 1, isoform 3 and isoform 4 but not isoform 2 interact with HSPA8/HSC70. Interacts with NR3C1. Interacts with the N-terminal region of STK19. Interacts with PPP1R15A. Interacts with BCL2 in an ATP-dependent manner. Isoform 2 does not interact with BCL2. {ECO:0000269\|PubMed:10477749, ECO:0000269\|PubMed:11222862, ECO:0000269\|PubMed:12724406, ECO:0000269\|PubMed:15986447, ECO:0000269\|PubMed:9305631, ECO:0000269\|PubMed:9582267, ECO:0000269\|PubMed:9679980}.
Tissue Specificity	Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level). {ECO:0000269\|PubMed:9679980}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org//Genes/BAG1ID742ch9p13.html";