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MT000076

Record overview

MITO ID	MT000076
Gene ID	596
Species	Homo sapiens (Human)
Gene Name	B-cell CLL/lymphoma 2
Gene Symbol	BCL2
Synonyms	Bcl-2; PPP1R50;
Alternate names	apoptosis regulator Bcl-2; protein phosphatase 1, regulatory subunit 50;
Chromosome	18
Map Location	18q21.3
Summary	This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008]
Orthologs	View orthologs and multiple alignments for BCL2

Proteins

apoptosis regulator Bcl-2 alpha isoform

Refseq ID:	NP_000624
Protein GI:	72198189
UniProt ID:	P10415
mRNA ID:	NM_000633
Length:	239
RefSeq Status:

apoptosis regulator Bcl-2 beta isoform
`MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQA GDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVE LYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK`

Refseq ID:	NP_000648
Protein GI:	72198346
UniProt ID:	P10415
mRNA ID:	NM_000657
Length:	205
RefSeq Status:

`MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQA GDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWVGALG DVSLG`