MitoProteome Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MT000076

Gene Information

Entrez Gene ID596
Gene NameB-cell CLL/lymphoma 2
Gene SymbolBCL2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005737 IDA:UniProtKBCcytoplasm
GO:0005829 IEA:EnsemblCcytosol
GO:0005783 IDA:UniProtKBCendoplasmic reticulum
GO:0005789 IEA:EnsemblCendoplasmic reticulum membrane
GO:0016020 IDA:MGICmembrane
GO:0005741 IDA:UniProtKBCmitochondrial outer membrane
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0043209 IEA:EnsemblCmyelin sheath
GO:0031965 IDA:UniProtKBCnuclear membrane
GO:0005634 IDA:MGICnucleus
GO:0046930 IDA:BHF-UCLCpore complex
GO:0051434 IPI:UniProtKBFBH3 domain binding
GO:0015267 IDA:BHF-UCLFchannel activity
GO:0016248 IDA:BHF-UCLFchannel inhibitor activity
GO:0042802 IPI:IntActFidentical protein binding
GO:0002020 IDA:UniProtKBFprotease binding
GO:0046982 IPI:UniProtKBFprotein heterodimerization activity
GO:0042803 IPI:UniProtKBFprotein homodimerization activity
GO:0043565 IDA:MGIFsequence-specific DNA binding
GO:0031625 IPI:UniProtKBFubiquitin protein ligase binding
GO:0007015 IEA:EnsemblPactin filament organization
GO:0006915 IDA:MGIPapoptotic process
GO:0007409 IEA:EnsemblPaxonogenesis
GO:0031103 IEA:EnsemblPaxon regeneration
GO:0001782 IEA:EnsemblPB cell homeostasis
GO:0002326 IEA:EnsemblPB cell lineage commitment
GO:0042100 IDA:MGIPB cell proliferation
GO:0050853 IMP:UniProtKBPB cell receptor signaling pathway
GO:0001662 IEA:EnsemblPbehavioral fear response
GO:0001658 IEA:EnsemblPbranching involved in ureteric bud morphogenesis
GO:0043375 IEA:EnsemblPCD8-positive, alpha-beta T cell lineage commitment
GO:0007569 IEA:EnsemblPcell aging
GO:0016049 IEA:EnsemblPcell growth
GO:0006974 IMP:UniProtKBPcellular response to DNA damage stimulus
GO:0042149 IEA:EnsemblPcellular response to glucose starvation
GO:0071456 IEA:EnsemblPcellular response to hypoxia
GO:0071310 IEA:EnsemblPcellular response to organic substance
GO:0021747 IEA:EnsemblPcochlear nucleus development
GO:0051607 IDA:UniProtKBPdefense response to virus
GO:0048589 IEA:EnsemblPdevelopmental growth
GO:0048546 IEA:EnsemblPdigestive tract morphogenesis
GO:0043583 IEA:EnsemblPear development
GO:0032469 TAS:UniProtKBPendoplasmic reticulum calcium ion homeostasis
GO:0097192 IEA:EnsemblPextrinsic apoptotic signaling pathway in absence of ligand
GO:0008625 IDA:MGIPextrinsic apoptotic signaling pathway via death domain receptors
GO:0007565 NAS:UniProtKBPfemale pregnancy
GO:0048041 IEA:EnsemblPfocal adhesion assembly
GO:0022612 IEA:EnsemblPgland morphogenesis
GO:0032835 IEA:EnsemblPglomerulus development
GO:0031069 IEA:EnsemblPhair follicle morphogenesis
GO:0048873 IEA:EnsemblPhomeostasis of number of cells within a tissue
GO:0006959 TAS:UniProtKBPhumoral immune response
GO:0045087 TAS:ReactomePinnate immune response
GO:0097193 TAS:ReactomePintrinsic apoptotic signaling pathway
GO:0008630 IBA:RefGenomePintrinsic apoptotic signaling pathway in response to DNA damage
GO:0070059 IDA:MGIPintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0008631 IEA:EnsemblPintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0002320 IEA:EnsemblPlymphoid progenitor cell differentiation
GO:0008584 IEA:EnsemblPmale gonad development
GO:0006582 IEA:EnsemblPmelanin metabolic process
GO:0030318 IEA:EnsemblPmelanocyte differentiation
GO:0014031 IEA:EnsemblPmesenchymal cell development
GO:0001656 IEA:EnsemblPmetanephros development
GO:2000811 IMP:UniProtKBPnegative regulation of anoikis
GO:0043066 IDA:UniProtKBPnegative regulation of apoptotic process
GO:2001234 IMP:UniProtKBPnegative regulation of apoptotic signaling pathway
GO:0010507 TAS:UniProtKBPnegative regulation of autophagy
GO:0010523 IEA:EnsemblPnegative regulation of calcium ion transport into cytosol
GO:0030308 IEA:EnsemblPnegative regulation of cell growth
GO:0030336 IEA:EnsemblPnegative regulation of cell migration
GO:0032848 IDA:UniProtKBPnegative regulation of cellular pH reduction
GO:2001240 IGI:MGIPnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2000134 IEA:EnsemblPnegative regulation of G1/S transition of mitotic cell cycle
GO:2001243 IDA:UniProtKBPnegative regulation of intrinsic apoptotic signaling pathway
GO:0051902 TAS:UniProtKBPnegative regulation of mitochondrial depolarization
GO:0045930 IEA:EnsemblPnegative regulation of mitotic cell cycle
GO:0033033 IEA:EnsemblPnegative regulation of myeloid cell apoptotic process
GO:0043524 IDA:MGIPnegative regulation of neuron apoptotic process
GO:0030279 IEA:EnsemblPnegative regulation of ossification
GO:0033689 IEA:EnsemblPnegative regulation of osteoblast proliferation
GO:0046671 IEA:EnsemblPnegative regulation of retinal cell programmed cell death
GO:0051402 TAS:HGNCPneuron apoptotic process
GO:0035872 TAS:ReactomePnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0048599 IEA:EnsemblPoocyte development
GO:0035265 IEA:EnsemblPorgan growth
GO:0001503 IEA:EnsemblPossification
GO:0001541 IEA:EnsemblPovarian follicle development
GO:0018105 IEA:EnsemblPpeptidyl-serine phosphorylation
GO:0018107 IEA:EnsemblPpeptidyl-threonine phosphorylation
GO:0048753 IEA:EnsemblPpigment granule organization
GO:0030890 IMP:UniProtKBPpositive regulation of B cell proliferation
GO:0043085 IEA:EnsemblPpositive regulation of catalytic activity
GO:0030307 IDA:MGIPpositive regulation of cell growth
GO:2001244 TAS:ReactomePpositive regulation of intrinsic apoptotic signaling pathway
GO:0045636 IEA:EnsemblPpositive regulation of melanocyte differentiation
GO:0040018 IEA:EnsemblPpositive regulation of multicellular organism growth
GO:0014042 IEA:EnsemblPpositive regulation of neuron maturation
GO:0033138 IEA:EnsemblPpositive regulation of peptidyl-serine phosphorylation
GO:1900740 TAS:ReactomePpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0048743 IEA:EnsemblPpositive regulation of skeletal muscle fiber development
GO:0014911 IEA:EnsemblPpositive regulation of smooth muscle cell migration
GO:0009791 IEA:EnsemblPpost-embryonic development
GO:0006470 IEA:EnsemblPprotein dephosphorylation
GO:0000209 IDA:MGIPprotein polyubiquitination
GO:0072593 IEA:EnsemblPreactive oxygen species metabolic process
GO:0051924 IDA:MGIPregulation of calcium ion transport
GO:0001952 IEA:EnsemblPregulation of cell-matrix adhesion
GO:0010559 IEA:EnsemblPregulation of glycoprotein biosynthetic process
GO:0046902 ISS:HGNCPregulation of mitochondrial membrane permeability
GO:0051881 ISS:HGNCPregulation of mitochondrial membrane potential
GO:0006808 IEA:EnsemblPregulation of nitrogen utilization
GO:0043497 IDA:UniProtKBPregulation of protein heterodimerization activity
GO:0043496 IDA:UniProtKBPregulation of protein homodimerization activity
GO:0031647 IEA:EnsemblPregulation of protein stability
GO:0022898 IDA:BHF-UCLPregulation of transmembrane transporter activity
GO:0045069 IEA:EnsemblPregulation of viral genome replication
GO:0001836 NAS:UniProtKBPrelease of cytochrome c from mitochondria
GO:0003014 IEA:EnsemblPrenal system process
GO:0001101 IEA:EnsemblPresponse to acid chemical
GO:0034097 IDA:MGIPresponse to cytokine
GO:0042493 IMP:UniProtKBPresponse to drug
GO:0010332 IEA:EnsemblPresponse to gamma radiation
GO:0051384 IEA:EnsemblPresponse to glucocorticoid
GO:0042542 IEA:EnsemblPresponse to hydrogen peroxide
GO:0010039 IDA:UniProtKBPresponse to iron ion
GO:0002931 IEA:EnsemblPresponse to ischemia
GO:0035094 IDA:UniProtKBPresponse to nicotine
GO:0009314 NAS:UniProtKBPresponse to radiation
GO:0009636 IDA:HGNCPresponse to toxic substance
GO:0010224 IEA:EnsemblPresponse to UV-B
GO:0016337 IEA:EnsemblPsingle organismal cell-cell adhesion
GO:0048536 IEA:EnsemblPspleen development
GO:0033077 IEA:EnsemblPT cell differentiation in thymus
GO:0043029 IEA:EnsemblPT cell homeostasis
GO:0048538 IEA:EnsemblPthymus development
GO:0055085 IDA:GOCPtransmembrane transport
KEGG Pathway Links
KEGG Pathway IDDescription
hsa04261Adrenergic signaling in cardiomyocytes
ko04261Adrenergic signaling in cardiomyocytes
hsa05014Amyotrophic lateral sclerosis (ALS)
ko05014Amyotrophic lateral sclerosis (ALS)
hsa04210Apoptosis
ko04210Apoptosis
hsa04725Cholinergic synapse
hsa05210Colorectal cancer
ko05210Colorectal cancer
hsa05169Epstein-Barr virus infection
ko05169Epstein-Barr virus infection
hsa04510Focal adhesion
ko04510Focal adhesion
hsa05161Hepatitis B
hsa04066HIF-1 signaling pathway
hsa05206MicroRNAs in cancer
ko05206MicroRNAs in cancer
hsa04722Neurotrophin signaling pathway
ko04722Neurotrophin signaling pathway
hsa04064NF-kappa B signaling pathway
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
ko04151PI3K-Akt signaling pathway
hsa05215Prostate cancer
ko05215Prostate cancer
hsa04141Protein processing in endoplasmic reticulum
ko04141Protein processing in endoplasmic reticulum
hsa05222Small cell lung cancer
ko05222Small cell lung cancer
hsa05145Toxoplasmosis
ko05145Toxoplasmosis
hsa05152Tuberculosis
ko05152Tuberculosis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_549Activation of BAD and translocation to mitochondria
REACT_697Activation of BH3-only proteins
REACT_578Apoptosis
REACT_330BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_6900Immune System
REACT_75900Inflammasomes
REACT_6802Innate Immune System
REACT_964Intrinsic Pathway for Apoptosis
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_75927The NLRP1 inflammasome