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MT000077

UniProt Annotations

Entry Information

Gene Name	BCL2-related protein A1
Protein Entry	B2LA1_HUMAN
UniProt ID	Q16548
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16548-1; Sequence=Displayed; Name=2; IsoId=Q16548-2; Sequence=VSP_043106;
Function	Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). {ECO:0000250}.
Induction	By phorbol ester and inflammatory cytokines, such as TNF or IL1B/interleukin-1 beta, but not by growth factors.
Similarity	Belongs to the Bcl-2 family. {ECO:0000305}.
Subcellular Location	Cytoplasm.
Subunit	Interacts directly with BAK1, BID, BMF and BBC3 (By similarity). Interacts directly with BCL2L11/BIM. Interacts with BAX isoform Sigma. Interacts directly with PMAIP1. Interacts with BOP/C22orf29. {ECO:0000250, ECO:0000269\|PubMed:10772918, ECO:0000269\|PubMed:18812174, ECO:0000269\|PubMed:23055042, ECO:0000269\|Ref.13, ECO:0000269\|Ref.14}.
Tissue Specificity	Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies.