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MT000085

UniProt Annotations

Entry Information

Gene Name	BCL2-interacting killer (apoptosis-inducing)
Protein Entry	BIK_HUMAN
UniProt ID	Q13323
Species	Human

Comments

Comment type	Description
Domain	Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Function	Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX. {ECO:0000269\|PubMed:8521816}.
Interaction	P10415:BCL2; NbExp=3; IntAct=EBI-700794, EBI-77694; Q07817:BCL2L1; NbExp=2; IntAct=EBI-700794, EBI-78035; Q07817-1:BCL2L1; NbExp=3; IntAct=EBI-700794, EBI-287195; Q92843:BCL2L2; NbExp=2; IntAct=EBI-700794, EBI-707714;
Ptm	Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1- induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism. {ECO:0000269\|PubMed:18953687}.
Subcellular Location	Endomembrane system; Single-pass membrane protein. Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Around the nuclear envelope, and in cytoplasmic membranes.
Subunit	Interacts with RHBDL4/RHBDD1. {ECO:0000269\|PubMed:18953687}.
Web Resource	Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/bik/";