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MT000088

UniProt Annotations

Entry Information

Gene Name	BCL2/adenovirus E1B 19kDa interacting protein 3-like
Protein Entry	BNI3L_HUMAN
UniProt ID	O60238
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O60238-1; Sequence=Displayed; Name=2; IsoId=O60238-2; Sequence=VSP_056248; Note=No experimental confirmation available.;
Function	Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. {ECO:0000269\|PubMed:10381623, ECO:0000269\|PubMed:21264228}.
Interaction	Self; NbExp=8; IntAct=EBI-849893, EBI-849893; Q9NQ11:ATP13A2; NbExp=2; IntAct=EBI-849893, EBI-6308763; Q92934:BAD; NbExp=2; IntAct=EBI-849893, EBI-700771; P10415:BCL2; NbExp=2; IntAct=EBI-849893, EBI-77694; Q12983:BNIP3; NbExp=9; IntAct=EBI-849893, EBI-749464; P03247:E1B (xeno); NbExp=7; IntAct=EBI-849893, EBI-849856;
Ptm	Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.
Sequence Caution	Sequence=CAI46217.1; Type=Erroneous termination; Positions=122; Note=Translated as Glu.; Evidence={ECO:0000305};
Similarity	Belongs to the NIP3 family. {ECO:0000305}.
Subcellular Location	Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Colocalizes with SPATA18 at the mitochondrion outer membrane.
Subunit	Self-associates. Interacts with BNIP3 and STEAP3. Interacts with human adenovirus-2 E1B 19 kDa protein. Interacts (via BH3 domain) with SPATA18 (via coiled-coil domains). {ECO:0000269\|PubMed:10381623, ECO:0000269\|PubMed:12606722, ECO:0000269\|PubMed:21264228}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BNIP3LID823ch8p21.html";