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MT000090

Record overview

MITO IDMT000090
Gene ID670
SpeciesHomo sapiens (Human)
Gene Namebiphenyl hydrolase-like (serine hydrolase)
Gene SymbolBPHL
SynonymsMCNAA; BPH-RP; VACVASE;
Alternate namesvalacyclovir hydrolase; valacyclovirase; biphenyl hydrolase-related protein; breast epithelial mucin-associated antigen;
Chromosome6
Map Location6p25
EC Number3.1.-.-
SummaryThis gene encodes a member of the serine protease family of hydrolytic enzymes which contain a serine in their active site. The encoded protein may play a role in activation of the antiviral prodrug valacyclovir. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009]
OrthologsView orthologs and multiple alignments for BPHL

Proteins

valacyclovir hydrolase isoform 1 precursor
Refseq ID:NP_004323
Protein GI:221316588
UniProt ID:Q86WA6
mRNA ID:NM_004332
Length:291
RefSeq Status:
MVAVLGGRGVLRLRLLLSALKPGIHVPRAGPAAAFGTSVTSAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETDFGPQLKNLNKKLFTVVAWDPRGYG
HSRPPDRDFPADFFERDAKDAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGANAYVTDEDSMIYEGIRDVSKWSERTRKPLEALYGYD
YFARTCEKWVDGIRQFKHLPDGNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFADEFNKLAEDFLQ
 
N
sig_peptide: 1..37
experiment: experimental evidence, no additional details recorded
note: {ECO:0000269|PubMed:12732646}; propagated from UniProtKB/Swiss-Prot (Q86WA6.1)
calculated_mol_wt: 3737
peptide sequence: 
MVAVLGGRGVLRLRLLLSALKPGIHVPRAGPAAAFGT

mat_peptide: 38..291
product: Valacyclovir hydrolase
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q86WA6.1)
calculated_mol_wt: 28824
peptide sequence: 
SVTSAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETDFGPQLKNLNKKLFTVVAWDPRGYGHSRPPDRDFPADFFERDAKDAVDLMKALKFKKVSLLG
WSDGGITALIAAAKYPSYIHKMVIWGANAYVTDEDSMIYEGIRDVSKWSERTRKPLEALYGYDYFARTCEKWVDGIRQFKHLPDGNICRHLLPRVQCPAL
IVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFADEFNKLAEDFLQ
 
valacyclovir hydrolase isoform 2
Refseq ID:NP_001289706
Protein GI:720642346
UniProt ID:
mRNA ID:NM_001302777
Length:274
RefSeq Status:
MPRNLLYSLLSSHLSPHFSTSVTSAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETDFGPQLKNLNKKLFTVVAWDPRGYGHSRPPDRDFPADFFERD
AKDAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGANAYVTDEDSMIYEGIRDVSKWSERTRKPLEALYGYDYFARTCEKWVDGIRQFK
HLPDGNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFADEFNKLAEDFLQ