MitoProteome Database

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MT000090

UniProt Annotations

Entry Information

Gene Name	biphenyl hydrolase-like (serine hydrolase)
Protein Entry
UniProt ID
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Beta; IsoId=Q86WA6-1; Sequence=Displayed; Name=2; Synonyms=Alpha; IsoId=Q86WA6-2; Sequence=VSP_009115;
Function	Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. {ECO:0000269\|PubMed:18256025}.
Similarity	Belongs to the AB hydrolase superfamily. Lipase family. {ECO:0000305}.
Subunit	Monomer. May also form homodimers. {ECO:0000269\|PubMed:18256025, ECO:0000269\|Ref.9}.
Tissue Specificity	Expressed at high levels in liver and kidney and lower levels in heart, intestine and skeletal muscle. {ECO:0000269\|PubMed:7759552}.