MitoProteome Database

MT000101

Gene Information

Entrez Gene ID	834
Gene Name	caspase 1, apoptosis-related cysteine peptidase
Gene Symbol	CASP1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0097169	IDA:UniProtKB	C	AIM2 inflammasome complex
GO:0005737	IBA:RefGenome	C	cytoplasm
GO:0005829	TAS:Reactome	C	cytosol
GO:0005576	IEA:Ensembl	C	extracellular region
GO:0072557	ISS:UniProtKB	C	IPAF inflammasome complex
GO:0072558	IDA:UniProtKB	C	NLRP1 inflammasome complex
GO:0072559	IDA:UniProtKB	C	NLRP3 inflammasome complex
GO:0008656	TAS:ProtInc	F	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0004197	IBA:RefGenome	F	cysteine-type endopeptidase activity
GO:0004175	IDA:ParkinsonsUK-UCL	F	endopeptidase activity
GO:0006919	TAS:GOC	P	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915	TAS:ProtInc	P	apoptotic process
GO:0071260	IEP:UniProtKB	P	cellular response to mechanical stimulus
GO:0071310	IDA:MGI	P	cellular response to organic substance
GO:0097194	IBA:RefGenome	P	execution phase of apoptosis
GO:0045087	TAS:Reactome	P	innate immune response
GO:0032611	IEA:Ensembl	P	interleukin-1 beta production
GO:0060081	IEA:Ensembl	P	membrane hyperpolarization
GO:0051882	IEA:Ensembl	P	mitochondrial depolarization
GO:0035872	TAS:Reactome	P	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043123	IEP:UniProtKB	P	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050717	IEA:Ensembl	P	positive regulation of interleukin-1 alpha secretion
GO:0050718	IEA:Ensembl	P	positive regulation of interleukin-1 beta secretion
GO:0097300	IEA:Ensembl	P	programmed necrotic cell death
GO:0006508	IDA:UniProtKB	P	proteolysis
GO:0070269	IEA:Ensembl	P	pyroptosis
GO:0050727	IBA:RefGenome	P	regulation of inflammatory response
GO:0033198	IEA:Ensembl	P	response to ATP
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0007165	TAS:ProtInc	P	signal transduction

KEGG Pathway Links

KEGG Pathway ID	Description
hsa05014	Amyotrophic lateral sclerosis (ALS)
ko05014	Amyotrophic lateral sclerosis (ALS)
hsa04623	Cytosolic DNA-sensing pathway
ko04623	Cytosolic DNA-sensing pathway
hsa05164	Influenza A
ko05164	Influenza A
hsa05134	Legionellosis
ko05134	Legionellosis
hsa04621	NOD-like receptor signaling pathway
ko04621	NOD-like receptor signaling pathway
hsa05133	Pertussis
ko05133	Pertussis
hsa05132	Salmonella infection
ko05132	Salmonella infection

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_75790	Cytokine Signaling in Immune system
REACT_6900	Immune System
REACT_75900	Inflammasomes
REACT_6802	Innate Immune System
REACT_23950	Interleukin-1 processing
REACT_75776	NOD1/2 Signaling Pathway
REACT_75913	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_22232	Signaling by Interleukins
REACT_75777	The AIM2 inflammasome
REACT_75892	The IPAF inflammasome
REACT_75808	The NLRP3 inflammasome