MitoProteome Database

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MT000101

UniProt Annotations

Entry Information

Gene Name	caspase 1, apoptosis-related cysteine peptidase
Protein Entry	CASP1_HUMAN
UniProt ID	P29466
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist.; Name=Alpha; IsoId=P29466-1; Sequence=Displayed; Name=Beta; IsoId=P29466-2; Sequence=VSP_000798; Name=Gamma; IsoId=P29466-3; Sequence=VSP_000799; Name=Delta; IsoId=P29466-4; Sequence=VSP_000799, VSP_000800; Note=Apoptosis inactive.; Name=Epsilon; IsoId=P29466-5; Sequence=VSP_000797; Note=Apoptosis inactive.;
Catalytic Activity	Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Tyr-Val-Ala- Asp-\|-.
Enzyme Regulation	Specifically inhibited by the cowpox virus Crma protein.
Function	Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. {ECO:0000269\|PubMed:15498465, ECO:0000269\|PubMed:7876192}.
Interaction	P09038:FGF2; NbExp=2; IntAct=EBI-516667, EBI-977447; P01583:IL1A; NbExp=3; IntAct=EBI-516667, EBI-1749782; Q9NPP4:NLRC4; NbExp=4; IntAct=EBI-516667, EBI-1222527;
Ptm	The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Sequence Caution	Sequence=AAT72297.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAT72297.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
Similarity	Belongs to the peptidase C14A family. {ECO:0000305}.
Similarity	Contains 1 CARD domain. {ECO:0000255\|PROSITE- ProRule:PRU00046}.
Subcellular Location	Cytoplasm.
Subunit	Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunit. The p20 subunit can also form a heterodimer with the epsilon isoform which then has an inhibitory effect. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and NALP2 and whose function would be the activation of proinflammatory caspases. Both the p10 and p20 subunits interact with MEFV. Interacts with CARD17/INCA and CARD18. {ECO:0000269\|PubMed:11051551, ECO:0000269\|PubMed:15383541, ECO:0000269\|PubMed:16785446, ECO:0000269\|PubMed:8044845, ECO:0000269\|PubMed:9987822}.
Tissue Specificity	Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. {ECO:0000269\|PubMed:15498465}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CASP1ID145ch11q22.html";