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MitoProteome Human Mitochondrial Protein Database
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Related Proteins
MT000102
Gene Information
Entrez Gene ID
835
Gene Name
caspase 2, apoptosis-related cysteine peptidase
Gene Symbol
CASP2
Species
Homo sapiens
Gene Ontology (GO Annotations)
GO ID
Source
Type
Description
GO:0005737
IBA:RefGenome
C
cytoplasm
GO:0005829
TAS:Reactome
C
cytosol
GO:0016020
IEA:Ensembl
C
membrane
GO:0005739
IEA:Ensembl
C
mitochondrion
GO:0005634
TAS:UniProtKB
C
nucleus
GO:0004197
IDA:UniProtKB
F
cysteine-type endopeptidase activity
GO:0097153
IEA:Ensembl
F
cysteine-type endopeptidase activity involved in apoptotic process
GO:0019899
ISS:UniProtKB
F
enzyme binding
GO:0019904
IPI:BHF-UCL
F
protein domain specific binding
GO:0007568
IEA:Ensembl
P
aging
GO:0006915
NAS:UniProtKB
P
apoptotic process
GO:0097190
TAS:UniProtKB
P
apoptotic signaling pathway
GO:0007420
IEA:Ensembl
P
brain development
GO:0071260
IEP:UniProtKB
P
cellular response to mechanical stimulus
GO:0006977
IMP:UniProtKB
P
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0035234
IEA:Ensembl
P
ectopic germ cell programmed cell death
GO:0097194
TAS:UniProtKB
P
execution phase of apoptosis
GO:0097192
IBA:RefGenome
P
extrinsic apoptotic signaling pathway in absence of ligand
GO:0008630
TAS:UniProtKB
P
intrinsic apoptotic signaling pathway in response to DNA damage
GO:0001554
IEA:Ensembl
P
luteolysis
GO:0003407
IEA:Ensembl
P
neural retina development
GO:0048011
TAS:Reactome
P
neurotrophin TRK receptor signaling pathway
GO:0043065
IDA:UniProtKB
P
positive regulation of apoptotic process
GO:2001235
IEA:Ensembl
P
positive regulation of apoptotic signaling pathway
GO:0043525
IEA:Ensembl
P
positive regulation of neuron apoptotic process
GO:0016485
IDA:BHF-UCL
P
protein processing
GO:0043281
TAS:Reactome
P
regulation of cysteine-type endopeptidase activity involved in apoptotic process
REACTOME Pathway Links
REACTOME Pathway ID
Description
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE
REACT_6900
Immune System
REACT_6802
Innate Immune System
REACT_13526
NADE modulates death signalling
REACT_75776
NOD1/2 Signaling Pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_13776
p75 NTR receptor-mediated signalling
REACT_11061
Signalling by NGF
REACT_111102
Signal Transduction
MitoProteome Human Mitochondrial Protein Database
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