MitoProteome Database

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MT000102

UniProt Annotations

Entry Information

Gene Name	caspase 2, apoptosis-related cysteine peptidase
Protein Entry	CASP2_HUMAN
UniProt ID	P42575
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Comment=Isoforms differ in the N- and C-termini.; Name=1; Synonyms=ICH-1L; IsoId=P42575-1; Sequence=Displayed; Note=Acts as a positive regulator of apoptosis.; Name=2; Synonyms=ICH-1S; IsoId=P42575-2; Sequence=VSP_000801, VSP_000802; Note=Acts as a negative regulator of apoptosis.; Name=3; Synonyms=Casp-2L-Pro; IsoId=P42575-3; Sequence=VSP_046280, VSP_046281, VSP_046282; Note=May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death.;
Catalytic Activity	Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-\|-.
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
Interaction	P42575-1:CASP2; NbExp=2; IntAct=EBI-520342, EBI-520357; P78560:CRADD; NbExp=9; IntAct=EBI-520342, EBI-520375; P78527:PRKDC; NbExp=4; IntAct=EBI-520342, EBI-352053;
Ptm	The mature protease can process its own propeptide, but not that of other caspases. {ECO:0000269\|PubMed:8654923}.
Sequence Caution	Sequence=AAA58959.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAO25653.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP22346.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP22349.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92877.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the peptidase C14A family. {ECO:0000305}.
Similarity	Contains 1 CARD domain. {ECO:0000255\|PROSITE- ProRule:PRU00046}.
Subunit	Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD. {ECO:0000269\|PubMed:12920126, ECO:0000269\|PubMed:15073321, ECO:0000269\|PubMed:16652156}.
Tissue Specificity	Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
Web Resource	Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/casp2/";