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MT000103

Record overview

MITO IDMT000103
Gene ID836
SpeciesHomo sapiens (Human)
Gene Namecaspase 3, apoptosis-related cysteine peptidase
Gene SymbolCASP3
SynonymsCPP32; SCA-1; CPP32B;
Alternate namescaspase-3; CASP-3; CPP-32; apopain; procaspase3; protein Yama; PARP cleavage protease; cysteine protease CPP32; SREBP cleavage activity 1; caspase 3, apoptosis-related cysteine protease;
Chromosome4
Map Location4q34
EC Number3.4.22.56
SummaryThis gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CASP3

Proteins

caspase-3 preproprotein
Refseq ID:NP_116786
Protein GI:14790115
UniProt ID:P42574
mRNA ID:NM_032991
Length:277
RefSeq Status:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELM
RDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTA
PGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
 
N
mat_peptide: 29..175
product: caspase-3 p17 subunit
calculated_mol_wt: 16615
peptide sequence: 
SGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIF
GTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETD

mat_peptide: 176..277
product: caspase-3 p12 subunit
calculated_mol_wt: 11896
peptide sequence: 
SGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYF
YH
 
caspase-3 preproprotein
Refseq ID:NP_004337
Protein GI:14790119
UniProt ID:P42574
mRNA ID:NM_004346
Length:277
RefSeq Status:
Protein sequence is identical to GI:14790115 (mRNA isoform)
 
N
mat_peptide: 29..175
product: caspase-3 p17 subunit
calculated_mol_wt: 16615
peptide sequence: 
SGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIF
GTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETD

mat_peptide: 176..277
product: caspase-3 p12 subunit
calculated_mol_wt: 11896
peptide sequence: 
SGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYF
YH

mat_peptide: 29..175
product: caspase-3 p17 subunit
calculated_mol_wt: 16615
peptide sequence: 
SGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIF
GTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETD

mat_peptide: 176..277
product: caspase-3 p12 subunit
calculated_mol_wt: 11896
peptide sequence: 
SGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYF
YH