MitoProteome Database

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MT000103

Gene Information

Entrez Gene ID836
Gene Namecaspase 3, apoptosis-related cysteine peptidase
Gene SymbolCASP3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IDA:UniProtKBCcytosol
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0005886 TAS:ReactomeCplasma membrane
GO:0004190 EXP:ReactomeFaspartic-type endopeptidase activity
GO:0004861 IEA:EnsemblFcyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0004197 IDA:UniProtKBFcysteine-type endopeptidase activity
GO:0097153 IMP:UniProtKBFcysteine-type endopeptidase activity involved in apoptotic process
GO:0097200 IMP:UniProtKBFcysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0008233 IDA:UniProtKBFpeptidase activity
GO:0008635 TAS:ReactomePactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0006309 TAS:ReactomePapoptotic DNA fragmentation
GO:0006915 TAS:ReactomePapoptotic process
GO:0097190 TAS:BHF-UCLPapoptotic signaling pathway
GO:0001782 IEA:EnsemblPB cell homeostasis
GO:0045165 IEA:EnsemblPcell fate commitment
GO:0006921 TAS:ReactomePcellular component disassembly involved in execution phase of apoptosis
GO:0006974 IEA:EnsemblPcellular response to DNA damage stimulus
GO:0030218 IDA:UniProtKBPerythrocyte differentiation
GO:0097194 IDA:UniProtKBPexecution phase of apoptosis
GO:0022617 TAS:ReactomePextracellular matrix disassembly
GO:0030198 TAS:ReactomePextracellular matrix organization
GO:0097192 IEA:EnsemblPextrinsic apoptotic signaling pathway in absence of ligand
GO:0008625 IEA:EnsemblPextrinsic apoptotic signaling pathway via death domain receptors
GO:0034349 IEA:EnsemblPglial cell apoptotic process
GO:0007507 IEA:EnsemblPheart development
GO:0035329 TAS:ReactomePhippo signaling
GO:0097193 TAS:ReactomePintrinsic apoptotic signaling pathway
GO:0008631 IEA:EnsemblPintrinsic apoptotic signaling pathway in response to oxidative stress
GO:0030216 IBA:RefGenomePkeratinocyte differentiation
GO:0046007 IEA:EnsemblPnegative regulation of activated T cell proliferation
GO:0043066 IGI:MGIPnegative regulation of apoptotic process
GO:0030889 IEA:EnsemblPnegative regulation of B cell proliferation
GO:0045736 IEA:EnsemblPnegative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051402 IEA:EnsemblPneuron apoptotic process
GO:0030182 IBA:RefGenomePneuron differentiation
GO:0048011 TAS:ReactomePneurotrophin TRK receptor signaling pathway
GO:0030220 TAS:UniProtKBPplatelet formation
GO:0043065 TAS:ReactomePpositive regulation of apoptotic process
GO:0043525 IEA:EnsemblPpositive regulation of neuron apoptotic process
GO:0006508 IDA:UniProtKBPproteolysis
GO:1902510 IEA:EnsemblPregulation of apoptotic DNA fragmentation
GO:0042981 TAS:ReactomePregulation of apoptotic process
GO:0043281 TAS:ReactomePregulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0001836 IEA:EnsemblPrelease of cytochrome c from mitochondria
GO:0034612 TAS:BHF-UCLPresponse to tumor necrosis factor
GO:0009411 IEA:EnsemblPresponse to UV
GO:0009611 IEA:EnsemblPresponse to wounding
GO:0007605 IEA:EnsemblPsensory perception of sound
GO:0043029 IEA:EnsemblPT cell homeostasis
KEGG Pathway Links
KEGG Pathway IDDescription
hsa05010Alzheimer's disease
ko05010Alzheimer's disease
hsa05146Amoebiasis
ko05146Amoebiasis
hsa05014Amyotrophic lateral sclerosis (ALS)
ko05014Amyotrophic lateral sclerosis (ALS)
hsa04210Apoptosis
ko04210Apoptosis
hsa05210Colorectal cancer
ko05210Colorectal cancer
hsa05120Epithelial cell signaling in Helicobacter pylori infection
ko05120Epithelial cell signaling in Helicobacter pylori infection
hsa05161Hepatitis B
hsa05168Herpes simplex infection
ko05168Herpes simplex infection
hsa05016Huntington's disease
ko05016Huntington's disease
hsa05134Legionellosis
ko05134Legionellosis
hsa04010MAPK signaling pathway
ko04010MAPK signaling pathway
hsa05206MicroRNAs in cancer
ko05206MicroRNAs in cancer
hsa04650Natural killer cell mediated cytotoxicity
ko04650Natural killer cell mediated cytotoxicity
hsa04932Non-alcoholic fatty liver disease (NAFLD)
ko04932Non-alcoholic fatty liver disease (NAFLD)
hsa04115p53 signaling pathway
ko04115p53 signaling pathway
hsa05012Parkinson's disease
hsa05200Pathways in cancer
hsa05133Pertussis
ko05133Pertussis
hsa05205Proteoglycans in cancer
ko05205Proteoglycans in cancer
hsa04726Serotonergic synapse
hsa04668TNF signaling pathway
ko04668TNF signaling pathway
hsa05145Toxoplasmosis
ko05145Toxoplasmosis
hsa05152Tuberculosis
ko05152Tuberculosis
hsa05203Viral carcinogenesis
ko05203Viral carcinogenesis
hsa05416Viral myocarditis
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_607Activation of caspases through apoptosome-mediated cleavage
REACT_13462Activation of DNA fragmentation factor
REACT_578Apoptosis
REACT_1213Apoptosis induced DNA fragmentation
REACT_13579Apoptotic cleavage of cell adhesion proteins
REACT_107Apoptotic cleavage of cellular proteins
REACT_995Apoptotic execution phase
REACT_963Apoptotic factor-mediated response
REACT_13541Caspase-mediated cleavage of cytoskeletal proteins
REACT_13720Cell death signalling via NRAGE, NRIF and NADE
REACT_831Cytochrome c-mediated apoptotic response
REACT_118572Degradation of the extracellular matrix
REACT_118779Extracellular matrix organization
REACT_964Intrinsic Pathway for Apoptosis
REACT_13526NADE modulates death signalling
REACT_13776p75 NTR receptor-mediated signalling
REACT_13648Regulation of Apoptosis
REACT_22128Role of DCC in regulating apoptosis
REACT_118607Signaling by Hippo
REACT_11061Signalling by NGF
REACT_111102Signal Transduction
REACT_2190SMAC binds to IAPs
REACT_666SMAC-mediated apoptotic response
REACT_1767SMAC-mediated dissociation of IAP:caspase complexes
REACT_13532Stimulation of the cell death response by PAK-2p34