MitoProteome Database

MT000105

Record overview

MITO ID	MT000105
Gene ID	840
Species	Homo sapiens (Human)
Gene Name	caspase 7, apoptosis-related cysteine peptidase
Gene Symbol	CASP7
Synonyms	MCH3; CMH-1; LICE2; CASP-7; ICE-LAP3;
Alternate names	caspase-7; apoptotic protease MCH-3; ICE-like apoptotic protease 3; caspase 7, apoptosis-related cysteine protease;
Chromosome	10
Map Location	10q25
EC Number	3.4.22.60
Summary	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Orthologs	View orthologs and multiple alignments for CASP7

Proteins

caspase-7 isoform alpha precursor

Refseq ID:	NP_203125
Protein GI:	15718700
UniProt ID:	P55210
mRNA ID:	NM_033339
Length:	303
RefSeq Status:

`MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKC FRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSG PINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY FSQ`

N
mat_peptide: 24..198
product: Caspase-7 subunit p20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 19719
peptide sequence: 
AKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLL
KKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQAD

mat_peptide: 207..303
product: Caspase-7 subunit p11
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 11338
peptide sequence: 
ANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ

caspase-7 isoform alpha precursor

Refseq ID:	NP_001253985
Protein GI:	388596698
UniProt ID:	P55210
mRNA ID:	NM_001267056
Length:	303
RefSeq Status:

Protein sequence is identical to GI:15718700 (mRNA isoform)

N
mat_peptide: 24..198
product: Caspase-7 subunit p20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 19719
peptide sequence: 
AKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLL
KKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQAD

mat_peptide: 207..303
product: Caspase-7 subunit p11
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 11338
peptide sequence: 
ANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ

mat_peptide: 24..198
product: Caspase-7 subunit p20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 19719
peptide sequence: 
AKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLL
KKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQAD

mat_peptide: 207..303
product: Caspase-7 subunit p11
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 11338
peptide sequence: 
ANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ

caspase-7 isoform alpha precursor

Refseq ID:	NP_001218
Protein GI:	4502581
UniProt ID:	P55210
mRNA ID:	NM_001227
Length:	303
RefSeq Status:

Protein sequence is identical to GI:15718700 (mRNA isoform)

N
mat_peptide: 24..198
product: Caspase-7 subunit p20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 19719
peptide sequence: 
AKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLL
KKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQAD

mat_peptide: 207..303
product: Caspase-7 subunit p11
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 11338
peptide sequence: 
ANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ

mat_peptide: 24..198
product: Caspase-7 subunit p20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 19719
peptide sequence: 
AKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLL
KKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQAD

mat_peptide: 207..303
product: Caspase-7 subunit p11
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 11338
peptide sequence: 
ANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ

mat_peptide: 24..198
product: Caspase-7 subunit p20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 19719
peptide sequence: 
AKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLL
KKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQAD

mat_peptide: 207..303
product: Caspase-7 subunit p11
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 11338
peptide sequence: 
ANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ

caspase-7 isoform beta

Refseq ID:	NP_203126
Protein GI:	15718702
UniProt ID:	P55210
mRNA ID:	NM_033340
Length:	253
RefSeq Status:

`MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKC FRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENMESCSVTQAGVQRRDLGRLQPPPPRLAEGPSLMMASRPTRGPSMTQMLILDT RSQWKLTSSSPIPRFQAITRGGAQEEAPGLCKPSAPSWRSTEKTWKSCRSSPG`

N
mat_peptide: 24..198
product: Caspase-7 subunit p20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 19719
peptide sequence: 
AKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLL
KKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQAD

mat_peptide: 207..303
product: Caspase-7 subunit p11
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 11338
peptide sequence: 
ANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ

caspase-7 isoform delta

Refseq ID:	NP_203124
Protein GI:	15718698
UniProt ID:	P55210
mRNA ID:	NM_033338
Length:	336
RefSeq Status:

caspase-7 isoform e
`MDCVGWPPGRKWHLEKNTSCGGSSGICASYVTQMADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKL GKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFR GDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVND RVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ`

Refseq ID:	NP_001253986
Protein GI:	388596700
UniProt ID:	P55210
mRNA ID:	NM_001267057
Length:	388
RefSeq Status:

`MRAGTRVALGSSTPAERTTPSQGRCKPRPALPRAAPPSAAPRLLVSLSLKGPQTLAAERRRETVPVPAALPPWERWQMIRAVLKSRGLRIQQMKIQWMLS QTGPRLYRPSSAPDSGTLYFTSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCS CAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPV EADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ`

N
mat_peptide: 24..198
product: Caspase-7 subunit p20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 19719
peptide sequence: 
AKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLL
KKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQAD

mat_peptide: 207..303
product: Caspase-7 subunit p11
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 11338
peptide sequence: 
ANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ

mat_peptide: 24..198
product: Caspase-7 subunit p20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 19719
peptide sequence: 
AKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLL
KKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQAD

mat_peptide: 207..303
product: Caspase-7 subunit p11
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 11338
peptide sequence: 
ANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ

caspase-7 isoform f

Refseq ID:	NP_001253987
Protein GI:	388596702
UniProt ID:	P55210
mRNA ID:	NM_001267058
Length:	278
RefSeq Status:

`MQRGLFSDGDTSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK ASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYST VPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ`

N
mat_peptide: 24..198
product: Caspase-7 subunit p20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 19719
peptide sequence: 
AKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLL
KKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQAD

mat_peptide: 207..303
product: Caspase-7 subunit p11
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 11338
peptide sequence: 
ANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ

mat_peptide: 24..198
product: Caspase-7 subunit p20
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 19719
peptide sequence: 
AKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLL
KKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQAD

mat_peptide: 207..303
product: Caspase-7 subunit p11
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P55210.1)
calculated_mol_wt: 11338
peptide sequence: 
ANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ