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MT000106

Record overview

MITO IDMT000106
Gene ID841
SpeciesHomo sapiens (Human)
Gene Namecaspase 8, apoptosis-related cysteine peptidase
Gene SymbolCASP8
SynonymsCAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8;
Alternate namescaspase-8; FADD-like ICE; MACH-alpha-1/2/3 protein; apoptotic protease Mch-5; MACH-beta-1/2/3/4 protein; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; FADD-homologous ICE/CED-3-like protease; caspase 8, apoptosis-related cysteine protease;
Chromosome2
Map Location2q33-q34
EC Number3.4.22.61
SummaryThis gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for CASP8

Proteins

caspase-8 isoform A precursor
Refseq ID:NP_001219
Protein GI:15718704
UniProt ID:Q14790
mRNA ID:NM_001228
Length:496
RefSeq Status:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISA
YRFHFCRMSWAEANSQCQTQSVPFWRRVDHLLIRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQIN
KSLLKIINDYEEFSKGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKP
HDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEM
DLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
 
N
mat_peptide: 217..374
product: caspase-8 isoform B subunit p18
calculated_mol_wt: 17902
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETD

mat_peptide: 385..479
product: caspase-8 isoform B subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD

mat_peptide: 202..308
product: caspase-8 isoform C subunit p18
calculated_mol_wt: 12365
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGII

mat_peptide: 370..464
product: caspase-8 isoform C subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD

mat_peptide: 202..308
product: caspase-8 isoform C subunit p18
calculated_mol_wt: 12365
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGII

mat_peptide: 370..464
product: caspase-8 isoform C subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD

mat_peptide: 276..382
product: caspase-8 isoform G subunit p18
calculated_mol_wt: 12365
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGII

mat_peptide: 444..538
product: caspase-8 isoform G subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD

mat_peptide: 234..340
product: caspase-8 isoform A subunit p18
calculated_mol_wt: 12365
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGII
 
caspase-8 isoform B precursor
Refseq ID:NP_203519
Protein GI:15718706
UniProt ID:Q14790
mRNA ID:NM_033355
Length:479
RefSeq Status:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISA
YRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGE
ELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFL
LGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
 
N
mat_peptide: 217..374
product: caspase-8 isoform B subunit p18
calculated_mol_wt: 17902
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETD

mat_peptide: 385..479
product: caspase-8 isoform B subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
 
caspase-8 isoform C precursor
Refseq ID:NP_001073593
Protein GI:122056474
UniProt ID:Q14790
mRNA ID:NM_001080124
Length:464
RefSeq Status:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISA
YRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKGEELCGVMTISDSPREQ
DSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCIL
SHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNP
AEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
 
N
mat_peptide: 217..374
product: caspase-8 isoform B subunit p18
calculated_mol_wt: 17902
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETD

mat_peptide: 385..479
product: caspase-8 isoform B subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD

mat_peptide: 202..308
product: caspase-8 isoform C subunit p18
calculated_mol_wt: 12365
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGII

mat_peptide: 370..464
product: caspase-8 isoform C subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD

mat_peptide: 202..308
product: caspase-8 isoform C subunit p18
calculated_mol_wt: 12365
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGII

mat_peptide: 370..464
product: caspase-8 isoform C subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
 
caspase-8 isoform C precursor
Refseq ID:NP_203520
Protein GI:15718708
UniProt ID:Q14790
mRNA ID:NM_033356
Length:464
RefSeq Status:
Protein sequence is identical to GI:122056474 (mRNA isoform)
 
N
mat_peptide: 217..374
product: caspase-8 isoform B subunit p18
calculated_mol_wt: 17902
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETD

mat_peptide: 385..479
product: caspase-8 isoform B subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD

mat_peptide: 202..308
product: caspase-8 isoform C subunit p18
calculated_mol_wt: 12365
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGII

mat_peptide: 370..464
product: caspase-8 isoform C subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
 
caspase-8 isoform E
Refseq ID:NP_203522
Protein GI:15718712
UniProt ID:Q14790
mRNA ID:NM_033358
Length:235
RefSeq Status:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISA
YRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNDF
GQSLPNEKQTSGILSDHQQSQFCKSTGESAQTSQH
 
N
mat_peptide: 217..374
product: caspase-8 isoform B subunit p18
calculated_mol_wt: 17902
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETD

mat_peptide: 385..479
product: caspase-8 isoform B subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD

mat_peptide: 202..308
product: caspase-8 isoform C subunit p18
calculated_mol_wt: 12365
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGII

mat_peptide: 370..464
product: caspase-8 isoform C subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
 
caspase-8 isoform G precursor
Refseq ID:NP_001073594
Protein GI:122056476
UniProt ID:Q14790
mRNA ID:NM_001080125
Length:538
RefSeq Status:
MEGGRRARVVIESKRNFFLGAFPTPFPAEHVELGRLGDSETAMVPGKGGADYILLPFKKMDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDA
LMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLD
IFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINN
HNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFT
GLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILT
ILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
 
N
mat_peptide: 217..374
product: caspase-8 isoform B subunit p18
calculated_mol_wt: 17902
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETD

mat_peptide: 385..479
product: caspase-8 isoform B subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD

mat_peptide: 202..308
product: caspase-8 isoform C subunit p18
calculated_mol_wt: 12365
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGII

mat_peptide: 370..464
product: caspase-8 isoform C subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD

mat_peptide: 202..308
product: caspase-8 isoform C subunit p18
calculated_mol_wt: 12365
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGII

mat_peptide: 370..464
product: caspase-8 isoform C subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD

mat_peptide: 276..382
product: caspase-8 isoform G subunit p18
calculated_mol_wt: 12365
peptide sequence: 
SESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILS
HGDKGII

mat_peptide: 444..538
product: caspase-8 isoform G subunit p10
calculated_mol_wt: 10889
peptide sequence: 
LSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD